Notice: Images are for illustration only and may not reflect the exact product you receive. Brand-name medications may look different depending on their country of origin—Canadian versions, for example, often include a "PR" symbol on the packaging. Rest assured, the medication, dosage, and active ingredients will be exactly as prescribed. Canada Pharmacy Store is committed to your health and safety, and we work only with licensed pharmacies to ensure you receive trusted, high-quality medication every time.
Prograf (Tacrolimus)
| Tacrolimus (Generic) Tacrolimus | ||||||
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Shipped from Canada | ||||||
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| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Tacrolimus (Generic) Tacrolimus | ||||||
|
Shipped from Mauritius | ||||||
| | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
General Medication Fact Sheet for Prograf
| Field | Information |
|---|---|
| Medication Name | Prograf |
| Generic Name | Tacrolimus |
| Boxed/Label Warning | Increased risk of serious infections and malignancies. |
| Purpose | Immunosuppressant used to prevent organ rejection after transplantation (e.g., liver, kidney, heart). |
| Mechanism of Action | Inhibits calcineurin, a protein phosphatase, thereby blocking T-cell activation and suppressing the immune system. |
| Dosage Forms | Oral capsules, oral granules, intravenous solution. |
| Available Strengths | Capsules: 0.5 mg, 1 mg, 5 mg; Granules: 0.2 mg. |
| Dosage Frequency | Typically twice daily, about 12 hours apart. |
| Common Side Effects | Tremor, headache, diarrhea, nausea, high blood pressure, kidney problems. |
| Serious Side Effects | Serious infections, malignancies (lymphoma, skin cancer), kidney damage, neurotoxicity, diabetes. |
| Drug Interactions | Many drugs can interact, including: antifungal medications (e.g., ketoconazole), antibiotics (e.g., erythromycin), calcium channel blockers (e.g., diltiazem), grapefruit juice. |
| Important Notes | Take exactly as prescribed; blood levels need to be monitored regularly. Avoid grapefruit juice. Report any signs of infection immediately. |
| Storage | Store at room temperature away from moisture and light. Keep capsules in original packaging. |
| Missed Dose | Take as soon as you remember, but do not double the dose to catch up. If close to the next dose, skip the missed dose and continue with the regular schedule. |
| Alternatives | Cyclosporine (Sandimmune, Neoral), Sirolimus (Rapamune), Mycophenolate mofetil (CellCept), Azathioprine (Imuran). |
Prograf Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Cyclosporine (Sandimmune, Neoral) | Calcineurin inhibitor | Another immunosuppressant used to prevent organ rejection. Requires blood level monitoring. |
| Sirolimus (Rapamune) | mTOR inhibitor | Immunosuppressant that works by a different mechanism than tacrolimus or Cyclosporine. |
| Mycophenolate mofetil (CellCept) | Inhibits purine synthesis | Immunosuppressant that suppresses B and T lymphocyte proliferation. |
| Azathioprine (Imuran) | Purine analog | Immunosuppressant and antimetabolite. |
Prograf Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Tremor | Serious infections (e.g., pneumonia, sepsis) |
| Headache | Malignancies (e.g., lymphoma, skin cancer) |
| Diarrhea | Kidney damage |
| Nausea | Neurotoxicity (e.g., seizures, confusion) |
| High blood pressure | Diabetes |
| Kidney problems | Posterior Reversible Encephalopathy Syndrome (PRES) |
Prograf Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Liver Transplant | 0.10 – 0.20 mg/kg/day (oral) or 0.03 – 0.05 mg/kg/day (IV) | Adjusted based on blood levels; typically 0.05 – 0.10 mg/kg/day. | Administer orally twice daily, approximately 12 hours apart. Take consistently with or without food. Monitor blood levels. |
| Kidney Transplant | 0.15 – 0.30 mg/kg/day (oral) or 0.05 – 0.10 mg/kg/day (IV) | Adjusted based on blood levels; typically 0.075 – 0.15 mg/kg/day. | Administer orally twice daily, approximately 12 hours apart. Take consistently with or without food. Monitor blood levels. |
| Heart Transplant | 0.075 mg/kg/day (oral) | Adjusted based on blood levels; typically 0.01 – 0.07 mg/kg/day. | Administer orally twice daily, approximately 12 hours apart. Take consistently with or without food. Monitor blood levels. |
Prograf Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $50 |
| Without Insurance (U.S.) | $300 |
| From CPS | $251 |
