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Prometrium (Progesterone)
| Progesterone (Generic) Progesterone | ||||||
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Shipped from Canada | ||||||
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General Medication Fact Sheet for Prometrium
| Field | Information |
|---|---|
| Medication Name | Prometrium |
| Generic Name | Progesterone |
| Boxed/Label Warning | Estrogen plus progestin therapy should not be used for the prevention of cardiovascular disease or dementia. Estrogen-alone therapy should not be used for the prevention of dementia. Increased risks of stroke and deep vein thrombosis (DVT) are associated with estrogen plus progestin therapy. Increased risk of endometrial cancer with unopposed estrogen therapy in a woman with a uterus. |
| Purpose | To treat secondary amenorrhea (absence of menstruation) and abnormal uterine bleeding due to hormonal imbalance. Also used as part of hormone replacement therapy (HRT) in women with a uterus to protect the endometrium when taking estrogen. |
| Mechanism of Action | Progesterone binds to progesterone receptors in the uterus, hypothalamus, and pituitary gland, modulating the hormonal balance and promoting endometrial maturation. |
| Dosage Forms | Oral capsules |
| Available Strengths | 100 mg, 200 mg |
| Dosage Frequency | Typically once or twice daily, depending on the condition being treated, or as directed by a healthcare provider. |
| Common Side Effects | Breast tenderness, headache, abdominal pain, fatigue, mood swings, dizziness. |
| Serious Side Effects | Blood clots (DVT, pulmonary embolism), stroke, heart attack, gallbladder disease, liver problems, allergic reactions. |
| Drug Interactions | Certain enzyme-inducing drugs (e.g., rifampin, carbamazepine, phenytoin), ketoconazole, other hormone therapies. |
| Important Notes | Inform your doctor if you have a history of blood clots, stroke, heart disease, liver disease, or cancer. Take as directed. May cause drowsiness. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember unless it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Medroxyprogesterone Acetate (Provera), Norethindrone, natural progesterone creams (though efficacy can vary). |
Prometrium Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Medroxyprogesterone Acetate (Provera) | Synthetic progestin; binds to progesterone receptors. | Available in tablet form; commonly used for secondary amenorrhea and abnormal uterine bleeding. |
| Norethindrone | Synthetic progestin; has both progestogenic and some androgenic activity. | Used in birth control pills and hormone replacement therapy. |
| Natural Progesterone Cream | Progesterone derived from plant sources. | Efficacy and absorption can vary; consult a healthcare provider. |
Prometrium Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Breast tenderness | Blood clots (DVT, pulmonary embolism) |
| Headache | Stroke |
| Abdominal pain | Heart attack |
| Fatigue | Gallbladder disease |
| Mood swings | Liver problems |
| Dizziness | Allergic reactions (rash, itching, swelling, difficulty breathing) |
Prometrium Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Secondary Amenorrhea | 400 mg | 400 mg orally once daily for 10 days | Administer during the last 10-12 days of an estrogen cycle. |
| Abnormal Uterine Bleeding | 400 mg | 400 mg orally once daily for 10 days | Administer during the last 10-12 days of an estrogen cycle. |
| HRT (with estrogen) | 200 mg | 200 mg orally once daily for 12 days per 28-day estrogen cycle. Or continuous 100 mg once daily. | Administer with estrogen. Can be given cyclically or continuously. |
