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General Medication Fact Sheet for Prucalopride
| Field | Information |
|---|---|
| Medication Name | Prucalopride |
| Generic Name | Prucalopride |
| Purpose | Treatment of chronic idiopathic constipation (CIC) in adults |
| Mechanism of Action | Selective serotonin 5-HT4 receptor agonist, which stimulates colonic motility |
| Dosage Forms | Oral tablets |
| Available Strengths | 1 mg, 2 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Headache, nausea, diarrhea, abdominal pain, dizziness |
| Serious Side Effects | Suicidal thoughts or behavior, severe diarrhea, persistent abdominal pain |
| Drug Interactions | Cisapride, erythromycin, ketoconazole (CYP3A4 inhibitors) may increase prucalopride levels |
| Important Notes | Use with caution in patients with severe or unstable cardiovascular disease; not recommended for patients with severe renal impairment |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take the missed dose as soon as you remember. If it is close to the time for your next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses at one time. |
| Alternatives | Linaclotide (Linzess), Lubiprostone (Amitiza), Plecanatide (Trulance) |
Prucalopride Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Linaclotide (Linzess) | Guanylate cyclase-C agonist | Increases intestinal fluid secretion and accelerates transit. |
| Lubiprostone (Amitiza) | Chloride channel activator | Increases intestinal fluid secretion. |
| Plecanatide (Trulance) | Guanylate cyclase-C agonist | Similar mechanism to linaclotide, increasing intestinal fluid secretion. |
| Polyethylene Glycol (Miralax) | Osmotic Laxative | Draws water into the colon to soften the stool. |
Prucalopride Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Headache | Suicidal thoughts or behavior |
| Nausea | Severe diarrhea |
| Diarrhea | Persistent abdominal pain |
| Abdominal pain | Depression |
| Dizziness | Worsening Constipation |
Prucalopride Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Chronic Idiopathic Constipation (CIC) | 1 mg or 2 mg | 2 mg once daily | May be taken with or without food. Start with 1 mg in older adults. |
