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Raloxifene (Generic)
| Evista Raloxifene Hydrochloride | ||||||
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Shipped from Canada | ||||||
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| Evista Raloxifene Hydrochloride | ||||||
Shipped from United Kingdom | ||||||
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| Evista Raloxifene | ||||||
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Shipped from Mauritius | ||||||
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General Medication Fact Sheet for Raloxifene
| Field | Information |
|---|---|
| Generic Name | Raloxifene |
| Brand Name Versions | Evista |
| Boxed/Label Warning | Raloxifene increases the risk of blood clots and stroke. |
| Purpose | Used to prevent and treat osteoporosis in postmenopausal women and to reduce the risk of invasive breast cancer in postmenopausal women with osteoporosis or at high risk for breast cancer. |
| Mechanism of Action | Selective estrogen receptor modulator (SERM) that acts like estrogen in some tissues (bone) and blocks estrogen in other tissues (uterus, breast). |
| Dosage Forms | Oral tablets |
| Available Strengths | 60 mg |
| Dosage Frequency | Typically once daily, or as directed by a healthcare provider. |
| Common Side Effects | Hot flashes, leg cramps, swelling in your hands and feet, joint pain. |
| Serious Side Effects | Blood clots (deep vein thrombosis, pulmonary embolism), stroke, vaginal bleeding, liver problems. |
| Drug Interactions | Warfarin, cholestyramine, diazepam, thyroid hormones. |
| Important Notes | Inform your doctor if you have a history of blood clots, stroke, heart disease, or liver problems. Raloxifene should not be taken by women who are pregnant or breastfeeding. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Alendronate, Risedronate, Ibandronate, Tamoxifen |
Raloxifene Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Alendronate (Fosamax) | Bisphosphonate; inhibits bone resorption by osteoclasts. | Commonly used for osteoporosis treatment. |
| Risedronate (Actonel) | Bisphosphonate; inhibits bone resorption by osteoclasts. | Similar to Alendronate; can be taken daily, weekly, or monthly. |
| Ibandronate (Boniva) | Bisphosphonate; inhibits bone resorption by osteoclasts. | Can be taken monthly or intravenously quarterly. |
| Tamoxifen | Selective estrogen receptor modulator (SERM) | Used to reduce the risk of breast cancer; has different effects on different tissues compared to Raloxifene. |
Raloxifene Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Hot flashes | Blood clots (DVT, pulmonary embolism) |
| Leg cramps | Stroke |
| Swelling in hands/feet | Vaginal bleeding |
| Joint pain | Liver problems |
Raloxifene Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Osteoporosis Prevention | 60 mg | 60 mg once daily | May be taken with or without food. |
| Osteoporosis Treatment | 60 mg | 60 mg once daily | May be taken with or without food. |
| Breast Cancer Risk Reduction | 60 mg | 60 mg once daily | May be taken with or without food. |
