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Rapamune (Sirolimus)
| Sirolimus (Generic) Sirolimus | ||||||
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Shipped from Mauritius | ||||||
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General Medication Fact Sheet for Rapamune
| Field | Information |
|---|---|
| Medication Name | Rapamune |
| Generic Name | Sirolimus |
| Boxed/Label Warning | Increased susceptibility to infection and the possible development of lymphoma and other cancers, as well as potential for serious and/or fatal infections. |
| Purpose | Immunosuppressant used to prevent organ rejection after kidney transplantation and treatment of lymphangioleiomyomatosis (LAM). |
| Mechanism of Action | Inhibits the mammalian target of rapamycin (mTOR), which is a key regulator of cell growth, proliferation, and survival. |
| Dosage Forms | Oral tablets, Oral solution |
| Available Strengths | Tablets: 0.5 mg, 1 mg, 2 mg. Oral solution: 1 mg/mL |
| Dosage Frequency | Once daily, or as directed by a healthcare provider. |
| Common Side Effects | Increased cholesterol and triglycerides, edema, hypertension, acne, rash, abdominal pain, diarrhea, nausea, headache, joint pain. |
| Serious Side Effects | Increased risk of infection, lymphoma and other cancers, kidney problems, lung problems, liver problems, severe allergic reactions, wound healing problems. |
| Drug Interactions | CYP3A4 inhibitors (e.g., ketoconazole, itraconazole), CYP3A4 inducers (e.g., rifampin, phenytoin), grapefruit juice, Cyclosporine, Tacrolimus, vaccines. |
| Important Notes | Monitor blood levels regularly. Avoid live vaccines. Report any signs of infection immediately. Females of reproductive potential should use effective contraception. |
| Storage | Store tablets at room temperature away from moisture and light. Store oral solution in the refrigerator after opening. |
| Missed Dose | Take as soon as you remember unless it is almost time for your next dose. Do not double the dose. |
| Alternatives | Tacrolimus, Cyclosporine, Azathioprine, Mycophenolate mofetil |
Rapamune Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Tacrolimus (Prograf) | Calcineurin inhibitor | Another immunosuppressant, often used in transplant patients. |
| Cyclosporine (Neoral, Sandimmune) | Calcineurin inhibitor | An immunosuppressant used to prevent organ rejection. |
| Azathioprine (Imuran) | Purine synthesis inhibitor | An immunosuppressant that works differently than Rapamune. |
| Mycophenolate mofetil (CellCept) | Inhibits purine synthesis | An immunosuppressant used to prevent organ rejection. |
Rapamune Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Increased cholesterol and triglycerides | Increased risk of infection |
| Edema (swelling) | Lymphoma and other cancers |
| Hypertension (high blood pressure) | Kidney problems |
| Acne | Lung problems |
| Rash | Liver problems |
| Abdominal pain | Severe allergic reactions |
| Diarrhea | Wound healing problems |
| Nausea | Thrombocytopenia (low platelet count) |
| Headache | Anemia |
| Joint Pain | Proteinuria |
Rapamune Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Kidney Transplantation (Adults) | Loading dose of 6 mg | 2 mg daily | Administer with Cyclosporine and corticosteroids during the initial period after transplantation. Adjust dose based on trough levels. |
| Kidney Transplantation (Children 13 years and older) | 3 mg/m²/day | Target trough level of 5-15 ng/mL | Administer with Cyclosporine and corticosteroids. Adjust dose based on trough levels. |
| Lymphangioleiomyomatosis (LAM) | 2 mg daily | Adjust to achieve trough concentration between 5 to 15 ng/mL | Adjust dose to maintain target trough concentrations. |
Rapamune Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $25 |
| Without Insurance (U.S.) | $1,300 |
| From CPS | $185 |
