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General Medication Fact Sheet for Rebif
| Field | Information |
|---|---|
| Medication Name | Rebif |
| Generic Name | Interferon beta-1a |
| Purpose | To treat relapsing forms of multiple sclerosis (MS). |
| Mechanism of Action | Modulates the body’s immune response to reduce inflammation and nerve damage in MS. |
| Dosage Forms | Subcutaneous injection |
| Available Strengths | 22 mcg, 44 mcg |
| Dosage Frequency | Three times per week |
| Common Side Effects | Flu-like symptoms (fever, chills, muscle aches), injection site reactions, abdominal pain, depression, elevated liver enzymes. |
| Serious Side Effects | Severe liver damage, depression or suicidal thoughts, seizures, serious allergic reactions. |
| Drug Interactions | Other immunomodulatory or immunosuppressant drugs, live vaccines, drugs affecting liver function. |
| Important Notes | Monitor for depression, liver function, and injection site reactions. Rotate injection sites. |
| Storage | Store refrigerated. Do not freeze. Protect from light. |
| Missed Dose | Inject as soon as you remember, but do not inject twice in the same day. Space doses at least 48 hours apart. |
| Alternatives | Avonex (interferon beta-1a), Betaseron (interferon beta-1b), Copaxone (glatiramer acetate) |
Rebif Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Avonex (interferon beta-1a) | Modulates immune response | Another interferon beta-1a product, administered intramuscularly. |
| Betaseron (interferon beta-1b) | Modulates immune response | Interferon beta-1b, administered subcutaneously every other day. |
| Copaxone (glatiramer acetate) | May modify immune processes involved in MS | A non-interferon option, administered subcutaneously. |
| Ocrevus (ocrelizumab) | Targets CD20-positive B cells | An anti-CD20 monoclonal antibody administered intravenously. |
Rebif Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Flu-like symptoms (fever, chills, muscle aches) | Severe liver damage |
| Injection site reactions (redness, pain, swelling) | Depression or suicidal thoughts |
| Abdominal pain | Seizures |
| Headache | Serious allergic reactions (rash, itching, swelling, difficulty breathing) |
| Depression | Worsening of heart problems |
Rebif Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Relapsing Multiple Sclerosis | Titrate from 20% of target dose (8.8 mcg) | 22 mcg or 44 mcg three times per week | Administer subcutaneously three times per week, preferably at the same time on the same days each week. Rotate injection sites. |
Rebif Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $25 |
| Without Insurance (U.S.) | $10,000 |
| From CPS | $460 |
