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Reglan (Metoclopramide)
| Metoclopramide (Generic) Metoclopramide Hydrochloride | ||||||
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Shipped from Canada | ||||||
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| Metoclopramide Hydrochloride (Generic) Metoclopramide Hydrochloride | ||||||
Shipped from United Kingdom | ||||||
| | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
General Medication Fact Sheet for Reglan
| Field | Information |
|---|---|
| Medication Name | Reglan |
| Generic Name | Metoclopramide |
| Boxed/Label Warning | Reglan can cause tardive dyskinesia, a serious movement disorder that is often irreversible. The risk of developing tardive dyskinesia increases with the duration of treatment and total cumulative dose. |
| Purpose | Used to relieve symptoms of slow stomach emptying (gastroparesis), nausea, vomiting, heartburn, and GERD. |
| Mechanism of Action | Blocks dopamine receptors and increases upper digestive tract motility without stimulating gastric, biliary, or pancreatic secretions. |
| Dosage Forms | Oral tablets, oral solution, injection |
| Available Strengths | 5 mg, 10 mg |
| Dosage Frequency | Typically taken 30 minutes before each meal and at bedtime, or as directed by a healthcare provider. |
| Common Side Effects | Drowsiness, fatigue, weakness, nausea, diarrhea, headache, dizziness. |
| Serious Side Effects | Tardive dyskinesia, restlessness, anxiety, depression, suicidal thoughts, neuroleptic malignant syndrome, seizures, high blood pressure. |
| Drug Interactions | Alcohol, sedatives, tranquilizers, narcotics, MAO inhibitors, anticholinergics, digoxin, cyclosporine. |
| Important Notes | Use with caution in patients with a history of depression or Parkinson’s disease. Do not use for more than 12 weeks due to the risk of tardive dyskinesia. Inform your doctor if you are pregnant or breastfeeding. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember. If it is close to your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose. |
| Alternatives | Domperidone, Erythromycin, Ondansetron, Prochlorperazine |
Reglan Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Domperidone | Dopamine receptor antagonist | Not FDA-approved in the U.S. but used in other countries for gastroparesis. |
| Erythromycin | Motilin receptor agonist | Increases gastric motility; may have tolerance issues with long-term use. |
| Ondansetron (Zofran) | Serotonin 5-HT3 receptor antagonist | Primarily used for nausea and vomiting, especially chemotherapy-induced. |
| Prochlorperazine (Compazine) | Dopamine receptor antagonist | Used for nausea, vomiting, and anxiety. Higher risk of extrapyramidal side effects. |
Reglan Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Drowsiness | Tardive dyskinesia (involuntary movements) |
| Fatigue | Neuroleptic Malignant Syndrome (NMS) |
| Weakness | Seizures |
| Nausea | Suicidal thoughts |
| Diarrhea | Restlessness, anxiety |
| Headache | Depression |
| Dizziness | High blood pressure |
Reglan Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Gastroparesis | 5-10 mg | 5-10 mg up to four times a day | Take 30 minutes before meals and at bedtime. Use the lowest dose possible and for the shortest duration. |
| Nausea and Vomiting | 10 mg | 10 mg up to four times a day | Take 30 minutes before meals and at bedtime. |
| Heartburn/GERD | 10-15 mg | 10-15 mg up to four times a day | Take before meals and at bedtime. |
