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General Medication Fact Sheet for Repatha
| Field | Information |
|---|---|
| Medication Name | Repatha |
| Generic Name | Evolocumab |
| Purpose | Lowers LDL cholesterol levels in adults with cardiovascular disease or familial hypercholesterolemia. |
| Mechanism of Action | PCSK9 inhibitor that prevents PCSK9 from binding to LDL receptors, increasing the number of LDL receptors available to clear LDL cholesterol from the blood. |
| Dosage Forms | Subcutaneous injection (prefilled syringe or autoinjector) |
| Available Strengths | 140 mg/mL |
| Dosage Frequency | 140 mg every two weeks or 420 mg once a month, administered subcutaneously. |
| Common Side Effects | Injection site reactions (redness, pain, bruising), nasopharyngitis (common cold), flu-like symptoms, back pain. |
| Serious Side Effects | Allergic reactions (rash, itching, swelling, difficulty breathing), serious injection site reactions. |
| Drug Interactions | No significant drug interactions reported; however, always inform your doctor of all medications and supplements you are taking. |
| Important Notes | This medication requires subcutaneous injection. Rotate injection sites. Follow your doctor’s instructions carefully. |
| Storage | Store in the refrigerator at 36°F to 46°F (2°C to 8°C) in the original carton to protect from light. Do not freeze. If needed, Repatha can be stored at room temperature up to 77°F (25°C) for a maximum of 30 days. |
| Missed Dose | Inject Repatha as soon as you remember, then resume your original schedule. |
| Alternatives | Praluent (alirocumab), statins (atorvastatin, rosuvastatin, simvastatin), Nexletol (bempedoic acid), Zetia (Ezetimibe). |
Repatha Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Praluent (alirocumab) | PCSK9 inhibitor | Administered via subcutaneous injection, similar to Repatha. |
| Atorvastatin (Lipitor) | HMG-CoA reductase inhibitor (statin) | Oral medication that lowers cholesterol by inhibiting cholesterol production in the liver. |
| rosuvastatin (Crestor) | HMG-CoA reductase inhibitor (statin) | Oral medication that lowers cholesterol by inhibiting cholesterol production in the liver. |
| Ezetimibe (Zetia) | Cholesterol absorption inhibitor | Oral medication that lowers cholesterol by inhibiting cholesterol absorption in the small intestine. |
| Bempedoic acid (Nexletol) | ATP citrate lyase inhibitor | An oral medication used with diet and maximally tolerated statin therapy to further lower LDL-C. |
Repatha Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Injection site reactions (redness, pain, bruising) | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Nasopharyngitis (common cold) | Serious injection site reactions |
Repatha Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Heterozygous Familial Hypercholesterolemia (HeFH) or Clinical Atherosclerotic Cardiovascular Disease | 140 mg | 140 mg every 2 weeks or 420 mg once a month | Administer subcutaneously. Rotate injection sites. |
| Homozygous Familial Hypercholesterolemia (HoFH) | 420 mg | 420 mg once a month | Administer subcutaneously. In patients undergoing apheresis, administer Repatha after the apheresis session. |
