Notice: Images are for illustration only and may not reflect the exact product you receive. Brand-name medications may look different depending on their country of origin—Canadian versions, for example, often include a "PR" symbol on the packaging. Rest assured, the medication, dosage, and active ingredients will be exactly as prescribed. Canada Pharmacy Store is committed to your health and safety, and we work only with licensed pharmacies to ensure you receive trusted, high-quality medication every time.
Description
General Medication Fact Sheet for Retevmo
| Field | Information |
|---|---|
| Medication Name | Retevmo |
| Generic Name | Selpercatinib |
| Boxed/Label Warning | Retevmo can cause serious side effects, including interstitial lung disease/pneumonitis, liver problems, high blood pressure, heart rhythm changes (QT prolongation), and increased risk of bleeding. It can also cause tumor lysis syndrome, severe hypersensitivity reactions, impaired wound healing, and thyroid dysfunction. Females of reproductive potential should use effective contraception during treatment and for 2 weeks after the last dose. Males with female partners of reproductive potential should use effective contraception during treatment and for 1 week after the last dose. |
| Purpose | Tyrosine kinase inhibitor used to treat certain types of cancers with RET (rearranged during transfection) alterations. |
| Mechanism of Action | Selectively inhibits RET kinase activity, leading to decreased cell proliferation and increased apoptosis in RET-altered cancer cells. |
| Dosage Forms | Oral capsules |
| Available Strengths | 40 mg, 80 mg |
| Dosage Frequency | Twice daily |
| Common Side Effects | Dry mouth, diarrhea, fatigue, edema, rash, abdominal pain, constipation, nausea, headache, cough, vomiting, dyspnea, decreased appetite, QT prolongation |
| Serious Side Effects | Interstitial lung disease/pneumonitis, hepatotoxicity, hypertension, QT prolongation, hemorrhagic events, hypersensitivity, tumor lysis syndrome, impaired wound healing, hypothyroidism |
| Drug Interactions | Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin), strong CYP3A4 inducers (e.g., rifampin, phenytoin), CYP3A4 substrates, P-gp substrates |
| Important Notes | Take Retevmo on an empty stomach, at least 2 hours before or 1 hour after a meal. Do not open or crush capsules. Monitor for signs and symptoms of interstitial lung disease/pneumonitis, hepatotoxicity, hypertension, and QT prolongation. Inform your doctor of any medications, supplements, and pre-existing medical conditions before starting treatment. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | If a dose is missed by more than 6 hours, skip the missed dose and take the next dose at its regularly scheduled time. Do not take two doses at the same time to make up for a missed dose. |
| Alternatives | Cabozantinib (Cabometyx), Vandetanib (Caprelsa), Other chemotherapy regimens (specific to cancer type and RET alteration) |
Retevmo Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Cabozantinib (Cabometyx) | Tyrosine kinase inhibitor | Inhibits multiple receptor tyrosine kinases including RET, VEGFR, MET, AXL, and FLT3. Used for medullary thyroid cancer and other cancers. |
| Vandetanib (Caprelsa) | Tyrosine kinase inhibitor | Inhibits RET, VEGFR, and EGFR. Used for medullary thyroid cancer. |
| Chemotherapy Regimens | Varies depending on regimen | Traditional cytotoxic agents used to kill cancer cells. Used when targeted therapies are not effective or appropriate. Specific regimens depend on cancer type. |
Retevmo Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Dry mouth | Interstitial lung disease/pneumonitis |
| Diarrhea | Hepatotoxicity (liver damage) |
| Fatigue | Hypertension (high blood pressure) |
| Edema (swelling) | QT Prolongation (heart rhythm changes) |
| Rash | Hemorrhagic events (bleeding) |
| Abdominal pain | Hypersensitivity reactions |
| Constipation | Tumor lysis syndrome |
| Nausea | Impaired wound healing |
| Headache | Hypothyroidism |
| Cough | None |
| Vomiting | None |
| Dyspnea | None |
| Decreased appetite | None |
Retevmo Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Non-Small Cell Lung Cancer (NSCLC) with RET fusion | 120 mg twice daily (for patients ≥50 kg); 160 mg/m² twice daily (for patients <50 kg) | Same as starting dose | Take on an empty stomach (at least 2 hours before or 1 hour after a meal). Dosage adjustments may be necessary for adverse reactions. |
| Medullary Thyroid Cancer (MTC) with RET mutation | 120 mg twice daily (for patients ≥50 kg); 160 mg/m² twice daily (for patients <50 kg) | Same as starting dose | Take on an empty stomach (at least 2 hours before or 1 hour after a meal). Dosage adjustments may be necessary for adverse reactions. |
| Other RET-altered solid tumors | 120 mg twice daily (for patients ≥50 kg); 160 mg/m² twice daily (for patients <50 kg) | Same as starting dose | Take on an empty stomach (at least 2 hours before or 1 hour after a meal). Dosage adjustments may be necessary for adverse reactions. |
Retevmo Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $60 |
| Without Insurance (U.S.) | $24,500 |
| From CPS | $6,105 |
Why Americans Buy Retevmo from Canada Pharmacy Store?
Why Americans Buy Retevmo from Canada Pharmacy Store?
Americans have trouble affording Retevmo due to numerous factors—but at Canada Pharmacy Store, we offer a safe, affordable alternative. That’s why thousands of Americans trust us to fill their prescriptions with real savings and real service.
Big Savings on U.S. Medications
Our customers save up to 80% on their Retevmo prescriptions compared to U.S. pharmacy prices by ordering through licensed Canadian and international pharmacies.
Free Prescription Transfers
We make it easy! Our pharmacy team can transfer your Retevmo prescriptions directly from your doctor or local pharmacy – completely free of charge.
Direct Access to Experts
Our licensed pharmacists are available to support you, answer your questions, and help ensure you’re confident in your treatment.
Referral Discounts
Spread the word—when you refer friends or family, you both save. It’s our way of saying thanks.
Discreet U.S. Shipping
All orders are packaged discreetly and shipped securely to your U.S. address, with your privacy and safety as top priorities.
Trusted by Americans Nationwide
With years of experience and verified medication sources, we’ve become a go-to solution for Americans looking to cut costs without compromising care.
How to Order Retevmo Online
How to Order Retevmo Online
Step 1
Select Your Prescribed Retevmo Dosage
Choose the strength and quantity as directed by your healthcare provider and add it to your cart.
Step 2
Proceed Through Secure Checkout
Follow the steps to complete your order and provide necessary shipping and payment details.
Step 3
Upload Your Retevmo Prescription
Submit a prescription from a licensed U.S. healthcare provider that matches your order.
At Canada Pharmacy Store, patient safety comes first. We strictly comply with prescription regulations and do not ship any medication without a valid, verifiable prescription. Orders may be declined if a prescription appears falsified or altered in any way. We take these precautions to protect your health and ensure lawful, responsible practices.
Guarantee
Our Guarantee When You Buy Retevmo Through Canada Pharmacy Store
At Canada Pharmacy Store, your safety and satisfaction are our top priorities. We supply only authentic, high-quality medications by working exclusively with licensed Canadian pharmacies and trusted international partners. Every order is filled in accordance with strict regulatory standards and includes medication that’s fully approved by Health Canada or other recognized health authorities such as the MHRA (UK), HSA (Singapore), and the Pharmacy Board of Mauritius.
The Retevmo you receive is the same active medication as what’s available in the U.S.—the only difference is the packaging, which reflects its country of origin. Our licensed healthcare professionals review each order carefully to ensure it matches your prescription exactly.
To get Retevmo at a lower price, simply place your order above or give us a call at 1-888-903-2240
Viewers Also Liked
