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General Medication Fact Sheet for Revolade
| Field | Information |
|---|---|
| Medication Name | Revolade |
| Generic Name | Eltrombopag |
| Boxed/Label Warning | Risk of hepatotoxicity; monitor liver function. Risk of thrombotic/thromboembolic complications. Risk of hematologic malignancies (MDS and AML). |
| Purpose | Used to treat low blood platelet counts in adults and children with chronic immune thrombocytopenia (ITP), severe aplastic anemia, and thrombocytopenia in patients with chronic hepatitis C. |
| Mechanism of Action | Binds to and activates the thrombopoietin (TPO) receptor, leading to increased platelet production. |
| Dosage Forms | Oral tablets |
| Available Strengths | 12.5 mg, 25 mg, 50 mg, 75 mg |
| Dosage Frequency | Once daily, as directed by a healthcare provider. |
| Common Side Effects | Nausea, fatigue, cough, headache, diarrhea. |
| Serious Side Effects | Liver problems, blood clots, bone marrow problems, bleeding. |
| Drug Interactions | Certain statins (e.g., atorvastatin, rosuvastatin), antacids containing aluminum, calcium, magnesium, or iron, lopinavir/ritonavir, cyclosporine. |
| Important Notes | Take on an empty stomach, at least 2 hours before or 4 hours after taking antacids containing aluminum, calcium, magnesium, or iron. Regular blood tests are required to monitor platelet counts and liver function. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember unless it is almost time for your next dose. Do not double the dose. |
| Alternatives | Romiplostim (Nplate), Prednisone, Danazol, Rituximab |
Revolade Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Romiplostim (Nplate) | TPO receptor agonist | Administered via subcutaneous injection. |
| Prednisone | Corticosteroid | Suppresses the immune system, reducing platelet destruction. Often used as a short-term treatment. |
| Danazol | Synthetic androgen | Increases platelet count in some patients with ITP. |
| Rituximab | Monoclonal antibody targeting CD20 | Depletes B cells, which can reduce antibody production against platelets. |
Revolade Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Liver problems (elevated liver enzymes, jaundice) |
| Fatigue | Thrombotic/thromboembolic complications (blood clots in legs, lungs, or brain) |
| Cough | Bone marrow problems (increased reticulin in bone marrow) |
| Headache | Bleeding (increased risk of bleeding if platelet counts become too high after stopping Revolade) |
| Diarrhea | Cataracts |
Revolade Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Chronic ITP (Adults) | 50 mg once daily | Adjust based on platelet count (target platelet count is 50 x 10^9/L to 200 x 10^9/L) | Take on an empty stomach, at least 2 hours before or 4 hours after taking certain medications or foods. |
| Chronic ITP (Children 6+ years) | 25 mg once daily | Adjust based on platelet count (target platelet count is 50 x 10^9/L to 200 x 10^9/L) | Take on an empty stomach, at least 2 hours before or 4 hours after taking certain medications or foods. |
| Severe Aplastic Anemia | 50 mg once daily | Adjust based on platelet count and hematologic response | Take on an empty stomach, at least 2 hours before or 4 hours after taking certain medications or foods. |
Revolade Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $50 |
| Without Insurance (U.S.) | $5,000 |
| From CPS | $2,867 |
