Notice: Images are for illustration only and may not reflect the exact product you receive. Brand-name medications may look different depending on their country of origin—Canadian versions, for example, often include a "PR" symbol on the packaging. Rest assured, the medication, dosage, and active ingredients will be exactly as prescribed. Canada Pharmacy Store is committed to your health and safety, and we work only with licensed pharmacies to ensure you receive trusted, high-quality medication every time.
Rheumatrex (Methotrexate)
| Methotrexate (Generic) Methotrexate Sodium | ||||||
|
Shipped from Canada | ||||||
| | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Methotrexate Sodium (Generic) Methotrexate Sodium | ||||||
Shipped from United Kingdom | ||||||
| | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
General Medication Fact Sheet for Rheumatrex
| Field | Information |
|---|---|
| Medication Name | Rheumatrex |
| Generic Name | Methotrexate |
| Boxed/Label Warning | Yes. Serious and sometimes fatal side effects including liver damage, lung disease, severe skin reactions, and bone marrow suppression. Women of childbearing age should use effective contraception. Contraindicated in pregnancy. |
| Purpose | Disease-modifying antirheumatic drug (DMARD) used to treat rheumatoid arthritis, psoriasis, and certain cancers. |
| Mechanism of Action | Inhibits dihydrofolate reductase, interfering with DNA synthesis, repair, and cellular replication. |
| Dosage Forms | Oral tablets, injectable solution |
| Available Strengths | 2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg |
| Dosage Frequency | Typically once weekly for rheumatoid arthritis and psoriasis; dosage varies for cancer treatment. |
| Common Side Effects | Nausea, vomiting, loss of appetite, fatigue, hair loss, mouth sores. |
| Serious Side Effects | Liver damage, lung disease, bone marrow suppression, infections, kidney problems, severe skin reactions. |
| Drug Interactions | NSAIDs, aspirin, certain antibiotics (e.g., trimethoprim-sulfamethoxazole), proton pump inhibitors (PPIs), alcohol. |
| Important Notes | Monitor liver function, blood counts, and kidney function regularly. Avoid alcohol. Use effective contraception. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Contact your doctor for instructions. Do not double the dose. |
| Alternatives | Sulfasalazine, Leflunomide (Arava), Hydroxychloroquine (Plaquenil), Tofacitinib (Xeljanz) |
Rheumatrex Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Sulfasalazine (Azulfidine) | Modulates inflammatory mediators. | Used for rheumatoid arthritis and ulcerative colitis. |
| Leflunomide (Arava) | Inhibits pyrimidine synthesis, affecting lymphocyte proliferation. | DMARD used for rheumatoid arthritis. |
| Hydroxychloroquine (Plaquenil) | Interferes with antigen processing and inhibits inflammatory cytokines. | Used for rheumatoid arthritis, lupus, and malaria. |
| Tofacitinib (Xeljanz) | Janus kinase (JAK) inhibitor, affecting cytokine signaling. | DMARD used for rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. |
Rheumatrex Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Liver damage (elevated liver enzymes, cirrhosis) |
| Vomiting | Lung disease (pneumonitis, pulmonary fibrosis) |
| Loss of appetite | Bone marrow suppression (low blood counts) |
| Fatigue | Infections (pneumonia, sepsis) |
| Hair loss | Kidney problems (renal failure) |
| Mouth sores | Severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis) |
Rheumatrex Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Rheumatoid Arthritis | 7.5 mg once weekly | 7.5-25 mg once weekly | Administer orally or by subcutaneous/intramuscular injection. Monitor blood counts and liver function. |
| Psoriasis | 10-25 mg once weekly | Varies depending on response and tolerance | Administer orally or by subcutaneous/intramuscular injection. Monitor blood counts and liver function. |
Rheumatrex Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $25 |
| Without Insurance (U.S.) | $500 |
| From CPS | $55 |
