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Rifaximin (Generic)
| Rifaximin Rifaximin | ||||||
Shipped from United Kingdom | ||||||
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General Medication Fact Sheet for Rifaximin
| Field | Information |
|---|---|
| Generic Name | Rifaximin |
| Brand Name Versions | Xifaxan |
| Purpose | Treatment of travelers’ diarrhea caused by noninvasive strains of E. coli, hepatic encephalopathy, and irritable bowel syndrome with diarrhea (IBS-D) |
| Mechanism of Action | Inhibits bacterial RNA synthesis by binding to bacterial DNA-dependent RNA polymerase |
| Dosage Forms | Oral tablets |
| Available Strengths | 200 mg, 550 mg |
| Dosage Frequency | Depends on the condition being treated; typically two to three times daily |
| Common Side Effects | Nausea, headache, dizziness, abdominal pain |
| Serious Side Effects | Severe allergic reactions (rash, itching, swelling, difficulty breathing), persistent diarrhea, C. difficile-associated diarrhea |
| Drug Interactions | P-glycoprotein (P-gp) inhibitors (e.g., cyclosporine) |
| Important Notes | Not effective against all types of diarrhea; use only for the specific conditions prescribed. |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Loperamide, Bismuth Subsalicylate, Ciprofloxacin, Fidaxomicin |
Rifaximin Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Loperamide (Imodium) | Opioid receptor agonist; slows bowel motility | Used for symptomatic relief of diarrhea. |
| Bismuth Subsalicylate (Pepto-Bismol) | Antisecretory and antimicrobial effects | Used for diarrhea and upset stomach. |
| Ciprofloxacin (Cipro) | Inhibits bacterial DNA gyrase | Antibiotic used for bacterial infections; consult a doctor. |
| Fidaxomicin (Dificid) | Inhibits bacterial RNA polymerase | Used for *C. difficile* infection. |
Rifaximin Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Severe allergic reactions (rash, itching, swelling, difficulty breathing) |
| Headache | Persistent diarrhea |
| Dizziness | Fever |
| Abdominal pain | Signs of a severe allergic reaction (rash, hives, severe dizziness, swelling of face/throat, trouble breathing) |
Rifaximin Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Travelers’ Diarrhea | 200 mg | 200 mg three times daily for 3 days | Take with or without food. |
| Hepatic Encephalopathy | 550 mg | 550 mg twice daily | Take with or without food. |
| IBS-D | 550 mg | 550 mg three times daily for 14 days | May be repeated up to two times for recurring symptoms. |
Rifaximin Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $80 |
| Without Insurance (U.S.) | $2,000 |
| From CPS | $95 |
