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General Medication Fact Sheet for Rinvoq
| Field | Information |
|---|---|
| Medication Name | Rinvoq |
| Generic Name | Upadacitinib |
| Boxed/Label Warning | Yes: Serious infections, malignancy, thrombosis, and mortality. |
| Purpose | Janus kinase (JAK) inhibitor used to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, ulcerative colitis, and atopic dermatitis. |
| Mechanism of Action | Selectively inhibits JAK enzymes, particularly JAK1, modulating the signaling pathways involved in inflammation and immune response. |
| Dosage Forms | Oral tablets |
| Available Strengths | 15 mg, 30 mg, 45 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Upper respiratory infections, nausea, cough, fever, acne, headache, increased blood creatine phosphokinase (CPK) levels. |
| Serious Side Effects | Serious infections (including tuberculosis), lymphoma and other cancers, blood clots, heart-related events, liver problems, gastrointestinal perforations. |
| Drug Interactions | Strong CYP3A4 inhibitors or inducers, certain immunosuppressants, live vaccines. |
| Important Notes | Increased risk of serious infections and malignancies. Not recommended for use with other potent immunosuppressants. Inform your doctor of any history of infections, cancer, or blood clots. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember unless it is almost time for your next dose. Do not double the dose. |
| Alternatives | Humira (adalimumab), Enbrel (etanercept), Xeljanz (tofacitinib), Olumiant (baricitinib), Methotrexate. |
Rinvoq Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Humira (adalimumab) | TNF-alpha inhibitor | Biologic DMARD; administered via injection. |
| Enbrel (etanercept) | TNF-alpha inhibitor | Biologic DMARD; administered via injection. |
| Xeljanz (tofacitinib) | Janus kinase (JAK) inhibitor | Similar mechanism to Rinvoq but less selective; available as an oral tablet. |
| Olumiant (baricitinib) | Janus kinase (JAK) inhibitor | Oral JAK inhibitor, may be an option based on disease and doctor’s recommendations. |
| Methotrexate | Antimetabolite and DMARD | Commonly used first-line treatment for RA. |
Rinvoq Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Upper respiratory infections (e.g., common cold, sinusitis) | Serious infections (e.g., tuberculosis, pneumonia) |
| Nausea | Lymphoma and other cancers |
| Cough | Blood clots (e.g., deep vein thrombosis, pulmonary embolism) |
| Fever | Heart-related events (e.g., heart attack, stroke) |
| Acne | Liver problems |
| Headache | Gastrointestinal perforations |
| Increased blood creatine phosphokinase (CPK) levels | Shingles (herpes zoster) reactivation |
Rinvoq Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Rheumatoid Arthritis | 15 mg once daily | 15 mg once daily | May be used as monotherapy or in combination with methotrexate or other non-biologic DMARDs. |
| Psoriatic Arthritis | 15 mg once daily | 15 mg once daily | May be used as monotherapy or in combination with non-biologic DMARDs. |
| Ankylosing Spondylitis | 15 mg once daily | 15 mg once daily | Used for adults with active ankylosing spondylitis who have had an inadequate response or intolerance to TNF blockers. |
| Ulcerative Colitis | 45 mg once daily | 15 mg or 30 mg once daily | 45 mg for induction; reduce to 15mg/30mg after induction. |
| Atopic Dermatitis | 15 mg or 30 mg once daily | 15 mg or 30 mg once daily | Dosage based on physician assessment of the patient’s AD. |
Rinvoq Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $60 |
| Without Insurance (U.S.) | $7,600 |
| From Canada | $2,441 |
