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General Medication Fact Sheet for Risperidone
| Field | Information |
|---|---|
| Medication Name | Risperidone |
| Generic Name | Risperidone |
| Boxed/Label Warning | Increased mortality in elderly patients with dementia-related psychosis. |
| Purpose | Atypical antipsychotic used to treat schizophrenia, bipolar disorder, and irritability associated with autistic disorder. |
| Mechanism of Action | Antagonizes dopamine D2 and serotonin 5-HT2A receptors in the brain. |
| Dosage Forms | Oral tablets, oral solution, intramuscular injection |
| Available Strengths | 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, 4 mg |
| Dosage Frequency | Typically once or twice daily, or as directed by a healthcare provider |
| Common Side Effects | Drowsiness, dizziness, increased appetite, weight gain, restlessness, tremors |
| Serious Side Effects | Neuroleptic malignant syndrome (NMS), tardive dyskinesia (TD), high blood sugar, stroke, seizures |
| Drug Interactions | Antihypertensives, CNS depressants (e.g., alcohol, benzodiazepines), carbamazepine, fluoxetine, paroxetine |
| Important Notes | May cause drowsiness; use caution when driving or operating machinery. Monitor blood sugar and cholesterol levels regularly. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember unless it is almost time for your next dose. Do not double the dose. |
| Alternatives | Quetiapine, Aripiprazole, Olanzapine, Ziprasidone |
Risperidone Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Quetiapine (Seroquel) | Antagonist of multiple neurotransmitter receptors including serotonin and dopamine receptors. | Also used for bipolar disorder and depression. |
| Aripiprazole (Abilify) | Partial agonist of dopamine D2 and serotonin 5-HT1A receptors, and antagonist of serotonin 5-HT2A receptors. | Also used for bipolar disorder, depression, and Tourette’s disorder. |
| Olanzapine (Zyprexa) | Antagonist of multiple neurotransmitter receptors including serotonin and dopamine receptors. | Associated with a higher risk of weight gain and metabolic side effects. |
| Ziprasidone (Geodon) | Antagonist of dopamine D2 and serotonin 5-HT2A receptors. | Should be taken with food to enhance absorption. |
Risperidone Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Drowsiness | Neuroleptic malignant syndrome (NMS) |
| Dizziness | Tardive dyskinesia (TD) |
| Increased appetite | High blood sugar (hyperglycemia) |
| Weight gain | Stroke |
| Restlessness | Seizures |
| Tremors | Prolactin elevation |
Risperidone Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Schizophrenia (Adults) | 2 mg per day | 4-8 mg per day | Administer once or twice daily. |
| Bipolar Disorder (Adults) | 2-3 mg per day | 1-6 mg per day | Administer once daily. |
| Irritability associated with Autistic Disorder (Children) | 0.25-0.5 mg per day | 0.5-3 mg per day | Administer once or twice daily. Dosage depends on weight. |
Risperidone Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $20 |
| Without Insurance (U.S.) | $90 |
| From CPS | $25 |
