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General Medication Fact Sheet for Rozerem
| Field | Information |
|---|---|
| Medication Name | Rozerem |
| Generic Name | Ramelteon |
| Purpose | Treatment of insomnia characterized by difficulty with sleep onset |
| Mechanism of Action | Selective agonist at melatonin MT1 and MT2 receptors in the suprachiasmatic nucleus (SCN) |
| Dosage Forms | Oral tablets |
| Available Strengths | 8 mg |
| Dosage Frequency | Once daily, 30 minutes before bedtime |
| Common Side Effects | Dizziness, somnolence, fatigue, nausea |
| Serious Side Effects | Worsening of depression, complex sleep-related behaviors (e.g., sleepwalking), decreased testosterone, increased prolactin levels |
| Drug Interactions | Fluvoxamine, rifampin, alcohol, other CNS depressants |
| Important Notes | Avoid use with alcohol or other sedatives. Take on an empty stomach. May impair daytime alertness. |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Skip the missed dose and take the next dose at the regular time. Do not double the dose. |
| Alternatives | Melatonin, Trazodone, Zaleplon (Sonata), Zolpidem (Ambien) |
Rozerem Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Melatonin | Agonist at melatonin receptors | Over-the-counter supplement; may be helpful for mild insomnia. |
| Trazodone | Serotonin antagonist and reuptake inhibitor (SARI) | Often used off-label for insomnia; can cause sedation. |
| Zaleplon (Sonata) | Nonbenzodiazepine hypnotic; GABA-A receptor agonist | Short half-life; useful for sleep onset insomnia. |
| Zolpidem (Ambien) | Nonbenzodiazepine hypnotic; GABA-A receptor agonist | More potent than zaleplon; risk of complex sleep behaviors. |
Rozerem Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Dizziness | Worsening of depression |
| Somnolence | Complex sleep-related behaviors (sleepwalking, sleep-driving) |
| Fatigue | Decreased testosterone levels |
| Nausea | Increased prolactin levels |
| Headache | Severe allergic reactions (rare) |
Rozerem Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Insomnia (Difficulty with Sleep Onset) | 8 mg | 8 mg | Take 30 minutes before bedtime on an empty stomach. |
Rozerem Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $55 |
| Without Insurance (U.S.) | $480 |
| From CPS | $423 |
