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General Medication Fact Sheet for Rukobia
| Field | Information |
|---|---|
| Medication Name | Rukobia |
| Generic Name | Fostemsavir |
| Purpose | Antiretroviral medication used to treat HIV-1 infection in adults with multi-drug resistant HIV-1 infection who are failing their current antiretroviral regimen due to resistance, intolerance or safety considerations. |
| Mechanism of Action | Fostemsavir is a prodrug that is converted to temsavir, which binds to the glycoprotein 120 (gp120) subunit of the HIV-1 envelope protein, preventing the virus from attaching to and entering human immune cells (CD4+ T cells). |
| Dosage Forms | Oral tablets |
| Available Strengths | 600 mg |
| Dosage Frequency | 1200 mg (two 600 mg tablets) twice daily with food. |
| Common Side Effects | Nausea, fatigue, diarrhea. |
| Serious Side Effects | Liver enzyme elevations, immune reconstitution syndrome, QTc prolongation |
| Drug Interactions | Strong CYP3A inducers (e.g., rifampin), strong CYP3A inhibitors (e.g., ketoconazole) and drugs that prolong the QTc interval |
| Important Notes | Rukobia must be taken with other antiretroviral medications; do not take Rukobia alone. Take with food to improve absorption. |
| Storage | Store at room temperature between 68°F to 77°F (20°C to 25°C). |
| Missed Dose | Take the missed dose as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at one time. |
| Alternatives | Darunavir (Prezista), Dolutegravir (Tivicay), Bictegravir (found in Biktarvy), Raltegravir (Isentress) |
Rukobia Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Darunavir (Prezista) | HIV-1 protease inhibitor | Often used in combination with other antiretroviral drugs. |
| Dolutegravir (Tivicay) | Integrase strand transfer inhibitor (INSTI) | Highly effective, usually part of a complete regimen. |
| Bictegravir (found in Biktarvy) | Integrase strand transfer inhibitor (INSTI) | Combined with tenofovir alafenamide and emtricitabine in a single tablet regimen. |
| Raltegravir (Isentress) | Integrase strand transfer inhibitor (INSTI) | An alternative INSTI. |
Rukobia Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Liver enzyme elevations |
| Fatigue | Immune Reconstitution Syndrome |
| Diarrhea | QTc Prolongation |
| Headache | Severe skin or hypersensitivity reactions |
Rukobia Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| HIV-1 Infection (Multi-Drug Resistant) | 1200 mg daily (two 600 mg tablets) | 1200 mg daily (two 600 mg tablets) | Take with food, twice daily, in combination with other antiretroviral medications. |
