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General Medication Fact Sheet for Rythmol
| Field | Information |
|---|---|
| Medication Name | Rythmol |
| Generic Name | Propafenone |
| Boxed/Label Warning | Increased Mortality in Patients with Structural Heart Disease |
| Purpose | Treatment of irregular heartbeats (arrhythmias), such as atrial fibrillation and paroxysmal supraventricular tachycardia (PSVT) |
| Mechanism of Action | Blocks sodium channels in the heart, slowing the conduction of electrical impulses and stabilizing heart rhythm. It also has some beta-blocking activity. |
| Dosage Forms | Oral tablets |
| Available Strengths | 150 mg, 225 mg, 300 mg |
| Dosage Frequency | Typically taken every 8 hours (three times daily) or as directed by a healthcare provider. |
| Common Side Effects | Dizziness, nausea, vomiting, constipation, fatigue, blurred vision, altered taste |
| Serious Side Effects | New or worsened arrhythmias, heart failure, chest pain, shortness of breath, liver problems (e.g., jaundice), low white blood cell count |
| Drug Interactions | Beta-blockers, digoxin, warfarin, certain antidepressants (SSRIs), cimetidine, quinidine, Amiodarone, local anesthetics |
| Important Notes | Take exactly as prescribed; do not stop taking suddenly without consulting your doctor. Regular ECG monitoring is required. Report any chest pain or shortness of breath immediately. Use with caution in patients with structural heart disease or heart failure. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. If you miss several doses, contact your healthcare provider. |
| Alternatives | Sotalol, Amiodarone, Flecainide, Dofetilide |
Rythmol Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Sotalol (Betapace) | Non-selective beta-adrenergic blocker with Class III antiarrhythmic properties | Also prolongs the QT interval; requires careful monitoring. |
| Amiodarone (Cordarone, Pacerone) | Class III antiarrhythmic that affects multiple ion channels | Has a long half-life and many potential side effects; often reserved for severe arrhythmias. |
| Flecainide (Tambocor) | Class IC antiarrhythmic that blocks sodium channels | Can be proarrhythmic; use is generally avoided in patients with structural heart disease. |
| Dofetilide (Tikosyn) | Class III antiarrhythmic that blocks potassium channels | Requires inpatient initiation due to the risk of QT prolongation and torsades de pointes. |
Rythmol Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Dizziness | New or worsened arrhythmias |
| Nausea | Heart failure |
| Vomiting | Chest pain |
| Constipation | Shortness of breath |
| Fatigue | Liver problems (jaundice, abdominal pain, dark urine) |
| Blurred vision | Low white blood cell count (increased risk of infection) |
| Altered taste | Prolonged QT interval |
Rythmol Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Atrial Fibrillation | 150 mg every 8 hours | 150-300 mg every 8 hours | Adjust dose based on response and tolerance. |
| Paroxysmal Supraventricular Tachycardia (PSVT) | 150 mg every 8 hours | 150-300 mg every 8 hours | Adjust dose based on response and tolerance. |
