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Salazopyrin (Sulfasalazine)
| Sulfasalazine ECT (Generic) Sulfasalazine | ||||||
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General Medication Fact Sheet for Salazopyrin
| Field | Information |
|---|---|
| Medication Name | Salazopyrin |
| Generic Name | Sulfasalazine |
| Boxed/Label Warning | May cause serious infections (including sepsis and pneumonia), blood disorders, liver damage, and hypersensitivity reactions. Patients should be monitored closely. |
| Purpose | Used to treat ulcerative colitis and rheumatoid arthritis |
| Mechanism of Action | The mechanism of action is not completely understood, but it is believed to have anti-inflammatory and immunomodulatory effects |
| Dosage Forms | Oral tablets |
| Available Strengths | 500 mg |
| Dosage Frequency | Typically two to four times daily, or as directed by a healthcare provider |
| Common Side Effects | Nausea, vomiting, diarrhea, loss of appetite, headache, skin rash |
| Serious Side Effects | Severe allergic reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis), blood disorders (agranulocytosis, aplastic anemia), liver problems, lung problems, kidney problems, increased risk of infections |
| Drug Interactions | Iron supplements, antibiotics (e.g., metronidazole), Methotrexate, Azathioprine, warfarin |
| Important Notes | Drink plenty of fluids while taking this medication; use caution if you have liver, kidney, or blood disorders; may cause photosensitivity |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Mesalamine, Azathioprine, Methotrexate, Infliximab |
Salazopyrin Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Mesalamine | Anti-inflammatory action in the colon | Used primarily for ulcerative colitis; available in oral and rectal formulations. |
| Azathioprine | Immunosuppressant; inhibits purine synthesis | Used for ulcerative colitis and rheumatoid arthritis. Requires regular blood monitoring. |
| Methotrexate | Immunosuppressant and anti-inflammatory | Used primarily for rheumatoid arthritis, but can be used off-label for ulcerative colitis. Requires regular monitoring. |
| Infliximab (Remicade) | TNF-alpha inhibitor | A biologic DMARD; used for both ulcerative colitis and rheumatoid arthritis when other treatments are not effective. |
Salazopyrin Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Severe allergic reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis) |
| Vomiting | Blood disorders (agranulocytosis, aplastic anemia) |
| Diarrhea | Liver problems |
| Loss of appetite | Lung problems |
| Headache | Kidney problems |
| Skin rash | Increased risk of infections |
Salazopyrin Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Ulcerative Colitis | 1-2 g daily | 2-4 g daily in divided doses | Take after meals to reduce gastrointestinal upset. |
| Rheumatoid Arthritis | 0.5-1 g daily | 2 g daily in divided doses | Increase dose gradually to minimize side effects. |
