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Salofalk Suppository (Mesalamine)
| 5-ASA (Generic) Mesalamine | ||||||
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Shipped from Canada | ||||||
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| Mesacol (Generic) Mesalamine | ||||||
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Shipped from Mauritius | ||||||
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Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Mesalamine (Generic) Mesalamine | ||||||
|
Shipped from Mauritius | ||||||
| | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
General Medication Fact Sheet for Salofalk
| Field | Information |
|---|---|
| Medication Name | Salofalk |
| Generic Name | Mesalamine |
| Boxed/Label Warning | Rarely, Salofalk can cause acute intolerance syndrome (symptoms include cramping, acute abdominal pain, bloody diarrhea, fever, headache, and rash). Discontinue treatment immediately if this occurs. |
| Purpose | Treatment of inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn’s disease. |
| Mechanism of Action | Mesalamine is thought to act topically in the colon to reduce inflammation. The exact mechanism is unknown, but it may involve inhibiting prostaglandin synthesis. |
| Dosage Forms | Oral tablets, rectal suppositories, rectal enemas |
| Available Strengths | 250 mg, 500 mg, 1000 mg (tablets); 500 mg, 1000 mg (suppositories); 4g/60mL (enema) |
| Dosage Frequency | Varies depending on the formulation and severity of the condition; typically taken 1-3 times daily for tablets, once or twice daily for suppositories, and once daily for enemas, or as directed by a healthcare provider. |
| Common Side Effects | Nausea, abdominal pain, diarrhea, headache, gas |
| Serious Side Effects | Kidney problems, liver problems, allergic reactions (rash, itching, swelling), worsening colitis symptoms, myocarditis, pericarditis. |
| Drug Interactions | Azathioprine, 6-mercaptopurine, NSAIDs (e.g., ibuprofen, naproxen) |
| Important Notes | Drink plenty of fluids while taking this medication. Notify your doctor if you have any kidney or liver problems. Monitor kidney function periodically, especially if you have pre-existing kidney disease or are taking other nephrotoxic drugs. |
| Storage | Store at room temperature away from moisture and light. Keep suppositories in the refrigerator but do not freeze. |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Sulfasalazine, Balsalazide, Olsalazine, Corticosteroids (e.g., Prednisone, Budesonide), Azathioprine |
Salofalk Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Sulfasalazine (Azulfidine) | Combination of sulfapyridine and mesalamine; anti-inflammatory properties. | Effective for ulcerative colitis and rheumatoid arthritis. Can cause more side effects than mesalamine alone. |
| Balsalazide (Colazal) | Prodrug that releases mesalamine in the colon. | Similar to mesalamine but may be better tolerated by some individuals. |
| Olsalazine (Dipentum) | Dimer of mesalamine; converted to mesalamine in the colon. | May cause more diarrhea than other mesalamine formulations. |
| Corticosteroids (Prednisone, Budesonide) | Reduces inflammation by suppressing the immune system. | Effective for short-term control of IBD symptoms but can cause significant side effects with long-term use. |
| Azathioprine (Imuran) | Immunosuppressant that reduces inflammation. | Used for maintenance therapy in IBD; requires regular monitoring for side effects. |
Salofalk Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Kidney problems |
| Abdominal pain | Liver problems |
| Diarrhea | Allergic reactions (rash, itching, swelling) |
| Headache | Worsening colitis symptoms |
| Gas | Myocarditis/Pericarditis (inflammation of the heart muscle/lining) |
Salofalk Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Ulcerative Colitis (Mild to Moderate) | 500 mg tablets three times daily | 500 mg tablets three times daily | Take with food. Dosage may vary depending on the specific formulation (tablets, enemas, suppositories). |
| Ulcerative Colitis (Maintenance) | 500 mg tablets three times daily | 500 mg tablets three times daily | Take with food. Aim to take it at the same time each day. |
| Crohn’s Disease (Off-label use) | Dosage varies depending on location and severity | Dosage varies depending on location and severity | Consult a healthcare provider for appropriate dosage. |
