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General Medication Fact Sheet for Sanctura
| Field | Information |
|---|---|
| Medication Name | Sanctura |
| Generic Name | Trospium Chloride |
| Purpose | Treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency. |
| Mechanism of Action | Anticholinergic agent; antagonizes acetylcholine at muscarinic receptors, reducing smooth muscle contraction in the bladder. |
| Dosage Forms | Oral tablets |
| Available Strengths | 20 mg, 30 mg (Sanctura XR) |
| Dosage Frequency | 20 mg twice daily or 30 mg once daily (Sanctura XR). Take on an empty stomach. |
| Common Side Effects | Dry mouth, constipation, blurred vision, headache |
| Serious Side Effects | Urinary retention, severe constipation, heat prostration (decreased sweating) |
| Drug Interactions | Amantadine, certain antihistamines (e.g., diphenhydramine), certain antidepressants (e.g., amitriptyline), digoxin, ketoconazole, metoclopramide |
| Important Notes | Use caution in patients with significant bladder outflow obstruction, decreased gastrointestinal motility, or narrow-angle glaucoma. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose. |
| Alternatives | Oxybutynin, Tolterodine (Detrol), Solifenacin (Vesicare), Mirabegron (Myrbetriq) |
Sanctura Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Oxybutynin (Ditropan) | Anticholinergic; muscarinic receptor antagonist | Available in immediate-release, extended-release, and topical formulations. |
| Tolterodine (Detrol) | Anticholinergic; muscarinic receptor antagonist | Available in immediate-release and extended-release formulations. |
| Solifenacin (Vesicare) | Anticholinergic; selective muscarinic M3 receptor antagonist | Once-daily dosing. |
| Mirabegron (Myrbetriq) | Beta-3 adrenergic agonist | Relaxes the bladder muscle to increase bladder capacity. Not an anticholinergic. |
Sanctura Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Dry mouth | Urinary retention |
| Constipation | Severe constipation/fecal impaction |
| Blurred vision | Heat prostration (decreased sweating, fever) |
| Headache | Confusion |
| Dry eyes | Hallucinations |
Sanctura Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Overactive Bladder (OAB) | 20 mg | 20 mg twice daily | Take on an empty stomach (at least 1 hour before or 2 hours after a meal). |
| Overactive Bladder (OAB) – Sanctura XR | 30 mg | 30 mg once daily | Take on an empty stomach (at least 1 hour before or 2 hours after a meal). |
Sanctura Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $30 |
| Without Insurance (U.S.) | $135 |
| From CPS | $99 |
