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General Medication Fact Sheet for Sancuso Transdermal Patch
| Field | Information |
|---|---|
| Medication Name | Sancuso Transdermal Patch |
| Generic Name | Granisetron |
| Purpose | Prevention of nausea and vomiting in patients receiving moderately and/or highly emetogenic chemotherapy. |
| Mechanism of Action | Selective 5-HT3 receptor antagonist, blocking serotonin from binding to receptors in the vomiting center of the brain and in the gastrointestinal tract. |
| Dosage Forms | Transdermal Patch |
| Available Strengths | 3.1 mg/24 hours |
| Dosage Frequency | Apply one patch 24-48 hours before chemotherapy and leave in place for up to 7 days (but no longer than 24 hours after chemotherapy). |
| Common Side Effects | Constipation, headache, application site reactions (e.g., redness, irritation). |
| Serious Side Effects | Serotonin syndrome, allergic reactions (e.g., rash, itching, swelling, difficulty breathing), QT prolongation. |
| Drug Interactions | Other serotonin-affecting drugs (e.g., SSRIs, SNRIs), drugs that prolong the QT interval. |
| Important Notes | Do not cut the patch. Avoid exposing the patch to direct sunlight. Monitor for signs of serotonin syndrome. |
| Storage | Store at room temperature (20-25°C/68-77°F). Protect from light and moisture. |
| Missed Dose | This medication is used preventatively; if a dose is missed, contact your doctor or pharmacist for further guidance. |
| Alternatives | Zofran (ondansetron), Aloxi (palonosetron), Compazine (prochlorperazine) |
Sancuso Transdermal Patch Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Zofran (ondansetron) | Selective 5-HT3 receptor antagonist | Available as oral tablets, oral solution, and IV injection. |
| Aloxi (palonosetron) | Selective 5-HT3 receptor antagonist | Longer half-life compared to ondansetron; typically given as a single IV dose. |
| Compazine (prochlorperazine) | Dopamine receptor antagonist | May cause drowsiness and extrapyramidal symptoms. |
Sancuso Transdermal Patch Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Constipation | Serotonin Syndrome (agitation, hallucinations, rapid heart rate, fever) |
| Headache | Allergic Reactions (rash, itching, swelling, difficulty breathing) |
| Application site reactions (redness, irritation) | QT Prolongation (irregular heart rhythm) |
Sancuso Transdermal Patch Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Chemotherapy-Induced Nausea and Vomiting | One patch | One patch | Apply 24-48 hours before chemotherapy; remove no later than 24 hours after chemotherapy. Apply to clean, dry, intact skin on the upper outer arm. |
