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General Medication Fact Sheet for Santyl Ointment
| Field | Information |
|---|---|
| Medication Name | Santyl Ointment |
| Generic Name | Collagenase |
| Purpose | Debriding (removing dead tissue from) chronic dermal ulcers and severely burned areas. |
| Mechanism of Action | Selectively digests necrotic tissue by breaking peptide bonds in collagen. |
| Dosage Forms | Topical ointment |
| Available Strengths | 250 units/gram |
| Dosage Frequency | Apply once daily, or as directed by a healthcare provider. |
| Common Side Effects | Burning, itching, irritation, pain. |
| Serious Side Effects | Severe allergic reaction (rash, itching/swelling, dizziness, trouble breathing). |
| Drug Interactions | Detergents, hexachlorophene, and antiseptics containing heavy metal ions (e.g., mercury, silver) or iodine. |
| Important Notes | Avoid getting the ointment in your eyes, nose, or mouth. Do not use on infected wounds. Use with caution in patients with sensitivity to collagenase. Consult a doctor if condition worsens or does not improve within a few weeks. |
| Storage | Store at room temperature (below 77°F or 25°C). Avoid excessive heat. |
| Missed Dose | Apply as soon as you remember. If it is almost time for your next application, skip the missed dose and continue with your regular schedule. Do not apply a double dose. |
| Alternatives | Accuzyme, Panafil, Granulex, Debrisan |
Santyl Ointment Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Accuzyme | Papain and urea combination for enzymatic debridement. | May be useful for liquefying necrotic tissue. |
| Panafil | Papain and urea combination for enzymatic debridement. | Another option for enzymatic debridement. |
| Granulex | Trypsin and Balsam Peru | Promotes wound healing. |
| Debrisan | Dextranomer | Absorbs exudate and debris from wound. |
Santyl Ointment Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Burning | Severe allergic reaction (rash, itching, swelling) |
| Itching | Difficulty breathing |
Santyl Ointment Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Chronic Dermal Ulcers | Apply thin layer | Apply thin layer once daily | Cleanse wound prior to application. Use sterile technique. |
| Burned Areas | Apply thin layer | Apply thin layer once daily | Cleanse wound prior to application. Use sterile technique. |
