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Savaysa (Edoxaban)
| Teva-Edoxaban (Generic) Edoxaban | ||||||
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Shipped from Canada | ||||||
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| Select product strength & quantity:
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General Medication Fact Sheet for Savaysa
| Field | Information |
|---|---|
| Medication Name | Savaysa |
| Generic Name | Edoxaban |
| Boxed/Label Warning | Premature discontinuation increases risk of thrombotic events; reduced efficacy in patients with creatinine clearance > 95 mL/min for stroke prevention in atrial fibrillation. |
| Purpose | Anticoagulant used to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation (AFib), and for the treatment and prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE). |
| Mechanism of Action | Directly inhibits factor Xa, a critical enzyme in the coagulation cascade, thereby preventing the formation of blood clots. |
| Dosage Forms | Oral tablets |
| Available Strengths | 15 mg, 30 mg, 60 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Bleeding (e.g., nosebleeds, bruising), anemia |
| Serious Side Effects | Major bleeding events (e.g., gastrointestinal bleeding, intracranial hemorrhage), allergic reactions |
| Drug Interactions | Rifampin, quinidine, verapamil, azole antifungals (e.g., ketoconazole), erythromycin, P-gp inducers and inhibitors, other anticoagulants, antiplatelet agents. |
| Important Notes | Inform your doctor if you have any kidney or liver problems, bleeding disorders, or are planning to have surgery. Avoid activities that may increase your risk of bleeding or injury. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take the missed dose as soon as you remember on the same day. Do not double your dose to make up for the missed dose. |
| Alternatives | Warfarin, Rivaroxaban (Xarelto), Apixaban (Eliquis), Dabigatran (Pradaxa) |
Savaysa Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Warfarin (Coumadin, Jantoven) | Vitamin K antagonist | Requires regular blood monitoring (INR) to maintain therapeutic range. |
| Rivaroxaban (Xarelto) | Direct factor Xa inhibitor | Once-daily oral anticoagulant; no routine blood monitoring required. |
| Apixaban (Eliquis) | Direct factor Xa inhibitor | Twice-daily oral anticoagulant; no routine blood monitoring required. |
| Dabigatran (Pradaxa) | Direct thrombin inhibitor | Oral anticoagulant; requires special storage conditions and specific management in case of bleeding. |
Savaysa Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Bleeding (nosebleeds, bruising) | Major bleeding (gastrointestinal, intracranial) |
| Anemia | Allergic reactions (rash, itching, swelling) |
| Skin rash | Thrombotic events after premature discontinuation |
Savaysa Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Nonvalvular Atrial Fibrillation | 60 mg | 60 mg once daily | Reduce dose to 30 mg if creatinine clearance is 15-50 mL/min or body weight is ≤60 kg or if taking certain P-gp inhibitors. |
| Treatment of DVT/PE | 60 mg | 60 mg once daily after initial heparin or LMWH treatment | Reduce dose to 30 mg if creatinine clearance is 15-50 mL/min or body weight is ≤60 kg or if taking certain P-gp inhibitors. |
| Prevention of Recurrent DVT/PE | 60 mg | 60 mg once daily | Reduce dose to 30 mg if creatinine clearance is 15-50 mL/min or body weight is ≤60 kg or if taking certain P-gp inhibitors. |
Savaysa Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $70 |
| Without Insurance (U.S.) | $550 |
| From CPS | $95 |
