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Selegiline (Generic)
| Eldepryl Selegiline Hydrochloride | ||||||
Shipped from United Kingdom | ||||||
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| Select product strength & quantity:
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General Medication Fact Sheet for Selegiline
| Field | Information |
|---|---|
| Generic Name | Selegiline |
| Brand Name Versions | Eldepryl, Emsam, Zelapar |
| Purpose | Treatment of Parkinson’s disease and major depressive disorder (transdermal patch) |
| Mechanism of Action | Selective irreversible inhibitor of monoamine oxidase type B (MAO-B) at lower doses; MAO-A inhibition may occur at higher doses. |
| Dosage Forms | Oral tablets, transdermal patch |
| Available Strengths | Tablets: 5 mg; Patch: 6 mg/24 hours, 9 mg/24 hours, 12 mg/24 hours |
| Dosage Frequency | Tablets: Typically once or twice daily; Patch: Once daily |
| Common Side Effects | Nausea, lightheadedness, dizziness, headache, insomnia, dry mouth, application site reactions (patch) |
| Serious Side Effects | High blood pressure, serotonin syndrome, hallucinations, abnormal involuntary movements, severe skin reactions (patch) |
| Drug Interactions | SSRIs, SNRIs, tricyclic antidepressants, MAOIs, certain pain medications (e.g., tramadol), stimulants, St. John’s Wort |
| Important Notes | Avoid foods high in tyramine when taking oral selegiline, especially at higher doses. Monitor blood pressure regularly. Discuss all medications and supplements with your doctor. |
| Storage | Store at room temperature away from moisture and light. Store patches in their original packaging. |
| Missed Dose | Tablets: Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. Patch: Apply a new patch as soon as you remember, but do not apply two patches at the same time. |
| Alternatives | Rasagiline, Pramipexole, Ropinirole, Amantadine, Levodopa/Carbidopa |
Selegiline Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Rasagiline (Azilect) | Selective irreversible MAO-B inhibitor | Used for Parkinson’s disease; similar to selegiline. |
| Pramipexole (Mirapex) | Dopamine receptor agonist | Stimulates dopamine receptors in the brain; used for Parkinson’s disease and restless legs syndrome. |
| Ropinirole (Requip) | Dopamine receptor agonist | Similar to Pramipexole; used for Parkinson’s disease and restless legs syndrome. |
| Amantadine (Gocovri) | Antiviral and antiparkinsonian agent; mechanism not fully understood | May help reduce dyskinesias in Parkinson’s disease. |
| Levodopa/Carbidopa (Sinemet) | Levodopa is a precursor to dopamine; carbidopa prevents levodopa from being broken down in the body | The gold standard treatment for Parkinson’s disease. |
Selegiline Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | High blood pressure (hypertensive crisis) |
| Lightheadedness | Serotonin syndrome |
| Dizziness | Hallucinations |
| Headache | Abnormal involuntary movements (dyskinesias) |
| Insomnia | Severe skin reactions (patch) |
| Dry mouth | Worsening of pre-existing psychiatric conditions |
| Application site reactions (patch) | Sudden sleep attacks |
Selegiline Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Parkinson’s Disease (Tablets) | 2.5 mg twice daily | 5 mg twice daily | Take with food to minimize nausea. Do not exceed 10 mg per day. |
| Parkinson’s Disease (Patch) | 6 mg/24 hours | 6-12 mg/24 hours | Apply to clean, dry, hairless skin on the upper torso, upper arm, or thigh. Rotate application sites. |
| Major Depressive Disorder (Patch) | 6 mg/24 hours | 6-12 mg/24 hours | For transdermal patch, follow similar directions as above. |
