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General Medication Fact Sheet for Sentinel Spectrum
| Field | Information |
|---|---|
| Medication Name | Sentinel Spectrum |
| Generic Name | Milbemycin Oxime/Lufenuron |
| Purpose | Prevents heartworm disease, controls adult roundworms, hookworms, whipworms, and tapeworms, and prevents flea eggs from hatching. |
| Mechanism of Action | Milbemycin Oxime interferes with nerve transmission in invertebrates, paralyzing and killing parasites. Lufenuron inhibits chitin synthesis, preventing flea eggs from hatching. |
| Dosage Forms | Chewable tablets |
| Available Strengths | Available in different strengths based on dog’s weight (e.g., 2-8 lbs, 8.1-25 lbs, 25.1-50 lbs, 50.1-100 lbs) |
| Dosage Frequency | Once a month |
| Common Side Effects | Vomiting, diarrhea, depression/lethargy, itching, hives, anorexia. |
| Serious Side Effects | Seizures, ataxia (loss of coordination), hypersensitivity reactions (anaphylaxis). |
| Drug Interactions | No significant drug interactions reported, but consult with a veterinarian before combining with other medications. |
| Important Notes | Administer orally once a month. Use with caution in dogs with a history of seizures. Safe for use in puppies over 6 weeks of age. |
| Storage | Store at room temperature, away from moisture and direct sunlight. |
| Missed Dose | Give the missed dose immediately and resume the monthly dosing schedule. |
| Alternatives | Heartgard Plus (ivermectin/pyrantel), Trifexis (spinosad/milbemycin oxime), Revolution (selamectin) |
Sentinel Spectrum Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Heartgard Plus (ivermectin/pyrantel) | Ivermectin paralyzes parasites; pyrantel treats roundworms and hookworms. | Protects against heartworm, roundworms, and hookworms. Does not protect against fleas. |
| Trifexis (spinosad/milbemycin oxime) | Spinosad kills fleas; milbemycin oxime prevents heartworm and treats intestinal worms. | Protects against heartworm, fleas, and intestinal worms (roundworms, hookworms, and whipworms). |
| Revolution (selamectin) | Selamectin paralyzes and kills parasites. | Protects against heartworm, fleas, ear mites, sarcoptic mange, and some ticks. Also treats roundworms and hookworms in cats. |
Sentinel Spectrum Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Vomiting | Seizures |
| Diarrhea | Ataxia (loss of coordination) |
| Depression/Lethargy | Hypersensitivity reactions (anaphylaxis – difficulty breathing, swelling) |
Sentinel Spectrum Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Heartworm Prevention, Intestinal Worms, Flea Control | Based on dog’s weight | Monthly, based on dog’s weight | Administer orally, once a month. Choose appropriate tablet strength based on the dog’s weight. |
