Notice: Images are for illustration only and may not reflect the exact product you receive. Brand-name medications may look different depending on their country of origin—Canadian versions, for example, often include a "PR" symbol on the packaging. Rest assured, the medication, dosage, and active ingredients will be exactly as prescribed. Canada Pharmacy Store is committed to your health and safety, and we work only with licensed pharmacies to ensure you receive trusted, high-quality medication every time.
Septra (Sulfamethoxazole & Trimethoprim)
| Sulfamethoxazole (Generic) Sulfamethoxazole, Trimethoprim | ||||||
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Shipped from Canada | ||||||
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| Sulfamethoxazole / Trimethoprim (Generic) Sulfamethoxazole, Trimethoprim | ||||||
|
Shipped from Canada | ||||||
| | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
General Medication Fact Sheet for Septra
| Field | Information |
|---|---|
| Medication Name | Septra |
| Generic Name | Sulfamethoxazole and Trimethoprim |
| Boxed/Label Warning | May cause serious skin reactions, blood disorders, liver damage, or kidney damage. Use with caution in patients with pre-existing blood disorders or impaired kidney or liver function. |
| Purpose | Antibiotic used to treat various bacterial infections |
| Mechanism of Action | Sulfamethoxazole inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA). Trimethoprim inhibits dihydrofolate reductase, another step in the folic acid synthesis pathway. This synergistic action blocks two consecutive steps in the bacterial folic acid pathway, leading to effective bacterial growth inhibition. |
| Dosage Forms | Oral tablets, Oral suspension |
| Available Strengths | Tablets: 400 mg sulfamethoxazole/80 mg trimethoprim, 800 mg sulfamethoxazole/160 mg trimethoprim; Suspension: 200 mg sulfamethoxazole/40 mg trimethoprim per 5 mL |
| Dosage Frequency | Typically twice daily, every 12 hours, or as directed by a healthcare provider |
| Common Side Effects | Nausea, vomiting, diarrhea, loss of appetite |
| Serious Side Effects | Severe skin rash (Stevens-Johnson syndrome, toxic epidermal necrolysis), blood disorders (thrombocytopenia, leukopenia, anemia), liver problems, kidney problems, allergic reactions, *C. difficile*-associated diarrhea |
| Drug Interactions | Warfarin, phenytoin, methotrexate, sulfonylureas, diuretics (especially thiazides), ACE inhibitors/ARBs |
| Important Notes | Drink plenty of water while taking this medication. May increase sensitivity to sunlight. Complete the full course of treatment, even if you feel better. |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Amoxicillin, Ciprofloxacin, Doxycycline, Cephalexin |
Septra Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Amoxicillin | Inhibits bacterial cell wall synthesis | A penicillin antibiotic, effective against many gram-positive bacteria. |
| Ciprofloxacin (Cipro) | Inhibits bacterial DNA gyrase and topoisomerase IV | A fluoroquinolone antibiotic, effective against many gram-negative bacteria. |
| Doxycycline | Inhibits bacterial protein synthesis | A tetracycline antibiotic, effective against a broad range of bacteria. |
| Cephalexin (Keflex) | Inhibits bacterial cell wall synthesis | A cephalosporin antibiotic, effective against many gram-positive bacteria. |
Septra Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Severe skin rash (Stevens-Johnson syndrome, toxic epidermal necrolysis) |
| Vomiting | Blood disorders (thrombocytopenia, leukopenia, anemia) |
| Diarrhea | Liver problems (jaundice, elevated liver enzymes) |
| Loss of appetite | Kidney problems (increased creatinine, kidney failure) |
| Headache | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Increased sensitivity to sunlight | *C. difficile*-associated diarrhea |
Septra Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Urinary Tract Infection (UTI) | 1 DS (800/160 mg) tablet | 1 DS (800/160 mg) tablet every 12 hours | Take with a full glass of water. Complete the full course of treatment. |
| Pneumocystis Pneumonia (PCP) Treatment | 15-20 mg (TMP) / kg / day | Divided every 6-8 hours | For severe infections. Dosing is based on trimethoprim (TMP) component. |
| Pneumocystis Pneumonia (PCP) Prophylaxis | 1 DS (800/160 mg) tablet | 1 DS (800/160 mg) tablet once daily | For prevention in immunocompromised individuals. |
