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General Medication Fact Sheet for Seretide Inhalers
| Field | Information |
|---|---|
| Medication Name | Seretide Inhaler |
| Generic Name | Fluticasone propionate and salmeterol |
| Boxed/Label Warning | Salmeterol, one of the medicines in Seretide Inhaler, can increase the risk of asthma-related death. |
| Purpose | Maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD) |
| Mechanism of Action | Fluticasone reduces inflammation in the lungs; salmeterol relaxes airway muscles, improving airflow. |
| Dosage Forms | Inhalation aerosol |
| Available Strengths | Fluticasone/Salmeterol: 50/25 mcg, 125/25 mcg, 250/25 mcg per inhalation |
| Dosage Frequency | Typically twice daily, approximately 12 hours apart |
| Common Side Effects | Headache, sore throat, upper respiratory infection, muscle pain |
| Serious Side Effects | Pneumonia, thrush (oral candidiasis), adrenal suppression, decreased bone mineral density, paradoxical bronchospasm, allergic reactions |
| Drug Interactions | Beta-blockers, monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, strong CYP3A4 inhibitors |
| Important Notes | Rinse mouth after each use to prevent thrush; use as a maintenance medication, not a rescue inhaler. |
| Storage | Store at room temperature away from heat and direct sunlight. |
| Missed Dose | Take as soon as you remember unless it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Symbicort (budesonide/formoterol), Dulera (mometasone/formoterol), Advair Diskus (fluticasone/salmeterol dry powder inhaler) |
Seretide Inhalers Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Symbicort (budesonide/formoterol) | Inhaled corticosteroid and long-acting beta-agonist (LABA) | Contains budesonide, an inhaled corticosteroid, and formoterol, a LABA. |
| Dulera (mometasone/formoterol) | Inhaled corticosteroid and long-acting beta-agonist (LABA) | Contains mometasone, an inhaled corticosteroid, and formoterol, a LABA. |
| Advair Diskus (fluticasone/salmeterol) | Inhaled corticosteroid and long-acting beta-agonist (LABA) | A dry powder inhaler containing fluticasone and salmeterol. |
| Singulair (montelukast) | Leukotriene receptor antagonist | Not a direct replacement for Seretide, but can be used as an add-on therapy for asthma. |
Seretide Inhalers Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Headache | Pneumonia |
| Sore throat | Thrush (oral candidiasis) |
| Upper respiratory infection | Adrenal suppression |
| Muscle pain | Decreased bone mineral density |
| Cough | Paradoxical bronchospasm |
| Hoarseness | Allergic reactions (rash, itching, swelling, difficulty breathing) |
Seretide Inhalers Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Asthma (Adults and Adolescents) | 50/25 mcg, 125/25 mcg, or 250/25 mcg | Same as starting dose, adjust based on response | Administer two inhalations twice daily. Rinse mouth after use. |
| Asthma (Children 4-11 years) | 50/25 mcg | 50/25 mcg twice daily | Administer two inhalations twice daily. Rinse mouth after use. |
| COPD (Adults) | 250/25 mcg | 250/25 mcg twice daily | Administer two inhalations twice daily. Rinse mouth after use. |

