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Seroquel (Quetiapine)
| Quetiapine Fumarate (Generic) Quetiapine Fumarate | ||||||
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Shipped from Canada | ||||||
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| Quetiapine Fumarate (Generic) Quetiapine Fumarate | ||||||
Shipped from United Kingdom | ||||||
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| Quetiapine Fumarate (Generic) Quetiapine Fumarate | ||||||
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Shipped from Mauritius | ||||||
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| Quetiapine XL (Generic) Quetiapine Fumarate | ||||||
Shipped from United Kingdom | ||||||
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| Quetiapine XR (Generic) Quetiapine Fumarate | ||||||
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Shipped from Canada | ||||||
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Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
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Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
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Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
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Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
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Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Quetiapine XR (Generic) Quetiapine Fumarate | ||||||
Shipped from United Kingdom | ||||||
| | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
General Medication Fact Sheet for Seroquel
| Field | Information |
|---|---|
| Medication Name | Seroquel |
| Generic Name | Quetiapine |
| Boxed/Label Warning | Increased risk of suicidal thoughts and behavior in children, adolescents, and young adults. Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. |
| Purpose | Treats schizophrenia, bipolar disorder (manic and depressive episodes), and as an add-on treatment for major depressive disorder (MDD). |
| Mechanism of Action | Antagonist at multiple neurotransmitter receptors in the brain, including serotonin (5-HT1A, 5-HT2A), dopamine (D1, D2), histamine (H1), and adrenergic (alpha1, alpha2) receptors. |
| Dosage Forms | Oral tablets (immediate-release and extended-release) |
| Available Strengths | 25 mg, 50 mg, 100 mg, 150 mg, 200 mg, 300 mg, 400 mg |
| Dosage Frequency | Typically once or twice daily, depending on the condition being treated and the specific formulation (immediate-release or extended-release). |
| Common Side Effects | Drowsiness, dizziness, dry mouth, constipation, increased appetite, weight gain, orthostatic hypotension (low blood pressure upon standing). |
| Serious Side Effects | Neuroleptic Malignant Syndrome (NMS), tardive dyskinesia (TD), metabolic changes (increased blood sugar, cholesterol, and triglycerides), cataracts, seizures, increased risk of stroke in elderly patients with dementia. |
| Drug Interactions | Alcohol, other CNS depressants (e.g., benzodiazepines, opioids), strong CYP3A4 inhibitors (e.g., ketoconazole), CYP3A4 inducers (e.g., phenytoin, carbamazepine, rifampin), antihypertensive medications. |
| Important Notes | Use caution when driving or operating machinery due to drowsiness. Monitor blood sugar, cholesterol, and weight regularly. Avoid alcohol. May cause orthostatic hypotension. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember, unless it is almost time for your next dose. Do not double the dose. |
| Alternatives | Risperidone (Risperdal), Olanzapine (Zyprexa), Aripiprazole (Abilify), Ziprasidone (Geodon). |
Seroquel Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Risperidone (Risperdal) | Dopamine and serotonin antagonist | Atypical antipsychotic used for schizophrenia, bipolar disorder, and irritability associated with autism. |
| Olanzapine (Zyprexa) | Dopamine and serotonin antagonist | Atypical antipsychotic used for schizophrenia and bipolar disorder. Known for significant weight gain. |
| Aripiprazole (Abilify) | Dopamine and serotonin partial agonist | Atypical antipsychotic used for schizophrenia, bipolar disorder, MDD (as adjunct), and Tourette’s disorder. |
| Ziprasidone (Geodon) | Dopamine and serotonin antagonist | Atypical antipsychotic used for schizophrenia and bipolar disorder. Should be taken with food. |
Seroquel Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Drowsiness | Neuroleptic Malignant Syndrome (NMS) |
| Dizziness | Tardive Dyskinesia (TD) |
| Dry mouth | Metabolic changes (high blood sugar, cholesterol, triglycerides) |
| Constipation | Cataracts |
| Increased appetite | Seizures |
| Weight gain | Increased risk of stroke (in elderly with dementia) |
| Orthostatic hypotension | Suicidal thoughts or behaviors (in young adults and adolescents) |
Seroquel Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Schizophrenia | 25 mg twice daily | 300-450 mg daily, in divided doses | Titrate gradually. |
| Bipolar Disorder (Mania) | 50 mg twice daily | 400-800 mg daily, in divided doses | Titrate gradually. |
| Bipolar Disorder (Depression) | 50 mg once daily | 300 mg once daily | Administer at bedtime. |
| MDD (Adjunct) | 25 mg once daily | 150-300 mg once daily | Administer at bedtime. |
