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General Medication Fact Sheet for Silenor
| Field | Information |
|---|---|
| Medication Name | Silenor |
| Generic Name | Doxepin |
| Boxed/Label Warning | Antidepressants may increase the risk of suicidal thoughts and behavior in children, teenagers, and young adults. |
| Purpose | Treatment of insomnia characterized by difficulty with sleep maintenance. |
| Mechanism of Action | Histamine H1 receptor antagonist; blocks histamine, promoting sleep. |
| Dosage Forms | Oral tablets |
| Available Strengths | 3 mg, 6 mg |
| Dosage Frequency | Once daily, 30 minutes before bedtime. |
| Common Side Effects | Somnolence, dizziness, nausea, fatigue. |
| Serious Side Effects | Suicidal thoughts/behavior, worsening depression, abnormal heart rhythm, urinary retention. |
| Drug Interactions | MAOIs, alcohol, other CNS depressants, anticholinergic drugs, cimetidine. |
| Important Notes | Avoid alcohol; use caution when driving or operating machinery; may cause withdrawal symptoms if stopped abruptly. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Skip the missed dose and take the next dose at the regular time. Do not double the dose. |
| Alternatives | Trazodone, Zolpidem (Ambien), Eszopiclone (Lunesta), Ramelteon (Rozerem) |
Silenor Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Trazodone | Serotonin antagonist and reuptake inhibitor (SARI) | Often used off-label for insomnia; can cause drowsiness. |
| Zolpidem (Ambien) | GABA-A receptor agonist | Sedative-hypnotic; can cause next-day impairment. |
| Eszopiclone (Lunesta) | GABA-A receptor agonist | Sedative-hypnotic; approved for long-term use. |
| Ramelteon (Rozerem) | Melatonin receptor agonist | Regulates the sleep-wake cycle. |
Silenor Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Somnolence | Suicidal thoughts/behavior |
| Dizziness | Worsening depression |
| Nausea | Abnormal heart rhythm (QT prolongation) |
| Fatigue | Urinary retention |
| Dry mouth | Severe allergic reaction (anaphylaxis) |
Silenor Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Insomnia (Sleep Maintenance) | 3 mg | 3 mg to 6 mg | Take 30 minutes before bedtime. Do not take with or immediately after a meal. |
Silenor Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $30 |
| Without Insurance (U.S.) | $50 |
| From CPS | $32 |
