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General Medication Fact Sheet for Simbrinza Opthalmic
| Field | Information |
|---|---|
| Medication Name | Simbrinza Opthalmic |
| Generic Name | Brimonidine Tartrate/Brinzolamide |
| Purpose | To lower intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. |
| Mechanism of Action | Reduces IOP by decreasing aqueous humor production (brinzolamide, a carbonic anhydrase inhibitor) and increasing uveoscleral outflow (brimonidine, an alpha-adrenergic receptor agonist). |
| Dosage Forms | Ophthalmic suspension (eye drops) |
| Available Strengths | Brimonidine 0.2%/Brinzolamide 1% |
| Dosage Frequency | One drop in the affected eye(s) three times daily. |
| Common Side Effects | Blurred vision, eye irritation, eye pain, dry eye, foreign body sensation, allergic conjunctivitis. |
| Serious Side Effects | Severe allergic reactions, significant decrease in blood pressure, central nervous system depression. |
| Drug Interactions | Concurrent administration with oral carbonic anhydrase inhibitors; use with caution in patients taking antihypertensives, cardiac glycosides, or tricyclic antidepressants. |
| Important Notes | Wash hands before use. Do not touch the dropper tip to any surface. Remove contact lenses before instilling drops and wait at least 15 minutes before reinserting them. Wait 5-10 minutes between using Simbrinza and other eye drops. |
| Storage | Store at room temperature between 15°C to 25°C (59°F to 77°F). Protect from light. |
| Missed Dose | If you miss a dose, instill it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose. |
| Alternatives | Combigan (brimonidine/Timolol), Azopt (brinzolamide), Alphagan P (brimonidine), Timolol |
Simbrinza Opthalmic Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Combigan (brimonidine/Timolol) | Alpha-adrenergic agonist/Beta-adrenergic blocker | Combination medication also used to lower IOP. |
| Azopt (brinzolamide) | Carbonic anhydrase inhibitor | Reduces aqueous humor production. |
| Alphagan P (brimonidine) | Alpha-adrenergic receptor agonist | Increases uveoscleral outflow and reduces aqueous humor production. |
| Timolol | Beta-adrenergic blocker | Decreases aqueous humor production. |
Simbrinza Opthalmic Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Blurred vision | Severe allergic reactions (rash, itching, swelling, difficulty breathing) |
| Eye irritation | Significant decrease in blood pressure |
| Eye pain | Central nervous system depression (drowsiness, fatigue) |
| Dry eye | Fainting |
| Foreign body sensation | Slow heart rate |
Simbrinza Opthalmic Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Open-Angle Glaucoma | One drop | One drop in the affected eye(s) three times daily | Administer every 8 hours. Shake well before use. |
| Ocular Hypertension | One drop | One drop in the affected eye(s) three times daily | Administer every 8 hours. Shake well before use. |
Simbrinza Opthalmic Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $30 |
| Without Insurance (U.S.) | $180 |
| From CPS | $60 |
