| Medication Name | Simcor |
| Generic Name | Simvastatin/Niacin |
| Boxed/Label Warning | Rhabdomyolysis (muscle damage) risk, especially with high doses of Simvastatin or when combined with certain medications. Niacin can cause liver problems. |
| Purpose | Combination medication used to lower LDL cholesterol and triglycerides while raising HDL cholesterol. |
| Mechanism of Action | Simvastatin inhibits HMG-CoA reductase, reducing cholesterol synthesis. Niacin reduces the production of VLDL, a precursor to LDL, and increases HDL levels. |
| Dosage Forms | Oral tablets |
| Available Strengths | Simvastatin/Niacin: 10/500 mg, 20/500 mg, 40/500 mg, 40/750 mg, 40/1000 mg |
| Dosage Frequency | Typically once daily in the evening, or as directed by a healthcare provider. |
| Common Side Effects | Flushing, itching, headache, nausea, diarrhea, muscle pain. |
| Serious Side Effects | Rhabdomyolysis (muscle breakdown), liver problems, high blood sugar, irregular heartbeat. |
| Drug Interactions | Other cholesterol-lowering medications (e.g., fibrates), certain antibiotics (e.g., erythromycin, clarithromycin), antifungals (e.g., itraconazole, ketoconazole), HIV protease inhibitors, nefazodone, large quantities of grapefruit juice, alcohol. |
| Important Notes | Should not be used in patients with active liver disease or unexplained persistent elevations in liver enzymes. Take with a low-fat meal. Avoid excessive alcohol consumption. Monitor liver function and muscle pain. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Simvastatin, Niacin, Atorvastatin, Rosuvastatin, Lovastatin, Fenofibrate, Gemfibrozil. |