Notice: Images are for illustration only and may not reflect the exact product you receive. Brand-name medications may look different depending on their country of origin—Canadian versions, for example, often include a "PR" symbol on the packaging. Rest assured, the medication, dosage, and active ingredients will be exactly as prescribed. Canada Pharmacy Store is committed to your health and safety, and we work only with licensed pharmacies to ensure you receive trusted, high-quality medication every time.
Description
General Medication Fact Sheet for Simparica Trio
| Field | Information |
|---|---|
| Medication Name | Simparica Trio |
| Generic Name | Sarolaner, Moxidectin, Pyrantel |
| Purpose | Prevents heartworm disease, kills fleas and ticks, and treats and controls roundworms and hookworms in dogs. |
| Mechanism of Action | Sarolaner: Blocks insect and acarine ligand-gated chloride channels (GABA-receptors and glutamate-receptors). Moxidectin: Interferes with nerve and muscle function in parasites. Pyrantel: Acts as a depolarizing neuromuscular blocking agent in parasites. |
| Dosage Forms | Oral chewable tablets |
| Available Strengths | Multiple strengths available based on dog’s weight: 2.5-5kg, 5-10kg, 10-20kg, 20-40kg, 40-60kg |
| Dosage Frequency | Once a month |
| Common Side Effects | Vomiting, diarrhea, lethargy, anorexia |
| Serious Side Effects | Seizures, ataxia (wobbly gait), tremors |
| Drug Interactions | No known significant drug interactions; use with caution with other macrocyclic lactones. |
| Important Notes | Use with caution in dogs with a history of seizures. Safe for use in puppies 8 weeks of age or older, weighing 2.5 lbs or greater. |
| Storage | Store at room temperature, between 59°F and 86°F (15°C and 30°C). |
| Missed Dose | Give the missed dose immediately and resume monthly dosing schedule. |
| Alternatives | Heartgard Plus, NexGard, Revolution, Interceptor Plus |
Simparica Trio Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Heartgard Plus (ivermectin/pyrantel) | Ivermectin: Interferes with nerve and muscle function in parasites. Pyrantel: Acts as a depolarizing neuromuscular blocking agent in parasites. | Prevents heartworm and treats/controls roundworms and hookworms. Does not protect against fleas or ticks. |
| NexGard (afoxolaner) | Blocks insect and acarine ligand-gated chloride channels (GABA-receptors and glutamate-receptors). | Kills fleas and ticks. Does not protect against heartworm or intestinal parasites. |
| Revolution (selamectin) | Interferes with nerve and muscle function in parasites. | Prevents heartworm, kills fleas, treats ear mites, and controls some ticks and worms. |
| Interceptor Plus (milbemycin oxime/praziquantel) | Milbemycin oxime: Interferes with nerve transmission in invertebrates. Praziquantel: Alters cell membrane permeability in cestodes. | Prevents heartworm and treats/controls roundworms, hookworms, whipworms, and tapeworms. Does not protect against fleas or ticks. |
Simparica Trio Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Vomiting | Seizures |
| Diarrhea | Ataxia (wobbly gait) |
| Lethargy | Tremors |
Simparica Trio Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Heartworm Prevention, Fleas, Ticks, Roundworms, Hookworms | One chewable tablet based on dog’s weight (2.5-5kg, 5-10kg, 10-20kg, 20-40kg, 40-60kg) | One chewable tablet monthly based on dog’s weight. | Administer orally once a month. Can be given with or without food. Choose the appropriate tablet strength based on the dog’s current weight. |
Why Americans Buy Simparica Trio from Canada Pharmacy Store?
Why Americans Buy Simparica Trio from Canada Pharmacy Store?
Americans have trouble affording Simparica Trio due to numerous factors—but at Canada Pharmacy Store, we offer a safe, affordable alternative. That’s why thousands of Americans trust us to fill their prescriptions with real savings and real service.
Big Savings on U.S. Medications
Our customers save up to 80% on their Simparica Trio prescriptions compared to U.S. pharmacy prices by ordering through licensed Canadian and international pharmacies.
Free Prescription Transfers
We make it easy! Our pharmacy team can transfer your Simparica Trio prescriptions directly from your doctor or local pharmacy – completely free of charge.
Direct Access to Experts
Our licensed pharmacists are available to support you, answer your questions, and help ensure you’re confident in your treatment.
Referral Discounts
Spread the word—when you refer friends or family, you both save. It’s our way of saying thanks.
Discreet U.S. Shipping
All orders are packaged discreetly and shipped securely to your U.S. address, with your privacy and safety as top priorities.
Trusted by Americans Nationwide
With years of experience and verified medication sources, we’ve become a go-to solution for Americans looking to cut costs without compromising care.
How to Order Simparica Trio Online
How to Order Simparica Trio Online
Step 1
Select Your Prescribed Simparica Trio Dosage
Choose the strength and quantity as directed by your healthcare provider and add it to your cart.
Step 2
Proceed Through Secure Checkout
Follow the steps to complete your order and provide necessary shipping and payment details.
Step 3
Upload Your Simparica Trio Prescription
Submit a prescription from a licensed U.S. healthcare provider that matches your order.
At Canada Pharmacy Store, patient safety comes first. We strictly comply with prescription regulations and do not ship any medication without a valid, verifiable prescription. Orders may be declined if a prescription appears falsified or altered in any way. We take these precautions to protect your health and ensure lawful, responsible practices.
Guarantee
Our Guarantee When You Buy Simparica Trio Through Canada Pharmacy Store
At Canada Pharmacy Store, your safety and satisfaction are our top priorities. We supply only authentic, high-quality medications by working exclusively with licensed Canadian pharmacies and trusted international partners. Every order is filled in accordance with strict regulatory standards and includes medication that’s fully approved by Health Canada or other recognized health authorities such as the MHRA (UK), HSA (Singapore), and the Pharmacy Board of Mauritius.
The Simparica Trio you receive is the same active medication as what’s available in the U.S.—the only difference is the packaging, which reflects its country of origin. Our licensed healthcare professionals review each order carefully to ensure it matches your prescription exactly.
To get Simparica Trio at a lower price, simply place your order above or give us a call at 1-888-903-2240
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