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General Medication Fact Sheet for Simponi
| Field | Information |
|---|---|
| Medication Name | Simponi |
| Generic Name | Golimumab |
| Boxed/Label Warning | Yes: Serious infections (e.g., tuberculosis, fungal infections) and lymphoma/other malignancies. |
| Purpose | Tumor necrosis factor (TNF) blocker used to treat autoimmune diseases. |
| Mechanism of Action | Binds to and neutralizes TNF-alpha, reducing inflammation. |
| Dosage Forms | Subcutaneous injection |
| Available Strengths | 50 mg/0.5 mL |
| Dosage Frequency | Varies depending on condition; typically once a month. |
| Common Side Effects | Injection site reactions, upper respiratory infections, headache. |
| Serious Side Effects | Serious infections (including TB), lymphoma, heart failure, nervous system disorders. |
| Drug Interactions | Other TNF inhibitors, anakinra, abatacept, live vaccines. |
| Important Notes | Screen for TB before starting; monitor for signs of infection; avoid live vaccines. |
| Storage | Refrigerate at 36°F to 46°F (2°C to 8°C); protect from light. |
| Missed Dose | Inject as soon as you remember, then resume your regular schedule. |
| Alternatives | Enbrel (etanercept), Humira (adalimumab), Remicade (infliximab), Cimzia (certolizumab pegol). |
Simponi Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Enbrel (etanercept) | TNF inhibitor | Administered via subcutaneous injection. |
| Humira (adalimumab) | TNF inhibitor | Administered via subcutaneous injection. |
| Remicade (infliximab) | TNF inhibitor | Administered via intravenous infusion. |
| Cimzia (certolizumab pegol) | TNF inhibitor | Administered via subcutaneous injection. |
Simponi Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Injection site reactions (redness, swelling, pain) | Serious infections (including TB, fungal infections) |
| Upper respiratory infections (sinusitis, bronchitis) | Lymphoma and other cancers |
| Headache | Heart failure (new or worsening) |
| Sore throat | Nervous system disorders (e.g., multiple sclerosis, optic neuritis) |
| Nausea | Allergic reactions (rash, itching, swelling, difficulty breathing) |
Simponi Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Rheumatoid Arthritis | 50 mg | 50 mg subcutaneously once a month | Administer on the same date each month. |
| Psoriatic Arthritis | 50 mg | 50 mg subcutaneously once a month | Administer on the same date each month. |
| Ankylosing Spondylitis | 50 mg | 50 mg subcutaneously once a month | Administer on the same date each month. |
| Ulcerative Colitis | 200 mg (Week 0), 100 mg (Week 2), then 50 mg | 50 mg subcutaneously every 4 weeks | For patients ≥ 40 kg; varies for lower weight. |
Simponi Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $100 |
| Without Insurance (U.S.) | $5,900 |
| From CPS | $1,550 |
