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Sinemet (Carbidopa,Levodopa)
| Carbidopa / Levodopa (Generic) Carbidopa, Levodopa | ||||||
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| Carbidopa CR (Generic) Carbidopa, Levodopa | ||||||
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Shipped from Canada | ||||||
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| Carbidopa CR (Generic) Carbidopa, Levodopa | ||||||
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Shipped from Mauritius | ||||||
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| Levocarb (Generic) Carbidopa, Levodopa | ||||||
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Shipped from Canada | ||||||
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General Medication Fact Sheet for Sinemet
| Field | Information |
|---|---|
| Medication Name | Sinemet |
| Generic Name | Carbidopa-Levodopa |
| Purpose | Treats symptoms of Parkinson’s disease, such as stiffness, tremors, spasms, and poor muscle control. |
| Mechanism of Action | Levodopa is converted to dopamine in the brain, replenishing dopamine levels. Carbidopa prevents levodopa from breaking down in the bloodstream, allowing more to reach the brain. |
| Dosage Forms | Oral tablets, Oral extended-release tablets |
| Available Strengths | Carbidopa/Levodopa: 10/100 mg, 25/100 mg, 25/250 mg; Carbidopa/Levodopa ER: 25/100 mg, 50/200 mg |
| Dosage Frequency | Typically three to four times daily for regular tablets; Extended-release tablets usually twice daily. Individualized dosing based on response. |
| Common Side Effects | Nausea, dizziness, lightheadedness, dyskinesia (involuntary movements), confusion, dry mouth, constipation. |
| Serious Side Effects | Hallucinations, severe mood changes, depression, unusual urges (gambling, sexual), uncontrolled movements, severe nausea/vomiting. |
| Drug Interactions | MAO inhibitors, iron supplements, certain antipsychotics, metoclopramide, phenytoin. |
| Important Notes | Take exactly as prescribed. Avoid high-protein meals when taking Sinemet. May cause drowsiness or dizziness. Rise slowly from sitting or lying down. Inform your doctor of all other medications you are taking. |
| Storage | Store at room temperature away from moisture and light. Keep out of reach of children. |
| Missed Dose | Take as soon as you remember unless it is almost time for your next dose. Do not double the dose. |
| Alternatives | Ropinirole (Requip), Pramipexole (Mirapex), Amantadine, Selegiline (Eldepryl) |
Sinemet Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Ropinirole (Requip) | Dopamine receptor agonist | Stimulates dopamine receptors in the brain. |
| Pramipexole (Mirapex) | Dopamine receptor agonist | Stimulates dopamine receptors in the brain. |
| Amantadine | Antiviral agent with anti-Parkinsonian effects | May help reduce dyskinesia. |
| Selegiline (Eldepryl) | MAO-B inhibitor | Inhibits the breakdown of dopamine in the brain. |
Sinemet Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Hallucinations |
| Dizziness | Severe mood changes |
| Lightheadedness | Depression |
| Dyskinesia (involuntary movements) | Unusual urges (gambling, sexual) |
| Confusion | Uncontrolled movements |
| Dry Mouth | Severe Nausea/Vomiting |
Sinemet Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Parkinson’s Disease | Carbidopa/Levodopa 25/100 mg three times daily | Individualized; may increase gradually based on response, up to a maximum daily dose. | Take with or without food; avoid high-protein meals around dosing. |
