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Sintrom (Acenocoumarol)
| Nicoumalone (Generic) Nicoumalone | ||||||
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Shipped from Mauritius | ||||||
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Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
General Medication Fact Sheet for Sintrom
| Field | Information |
|---|---|
| Medication Name | Sintrom |
| Generic Name | Acenocoumarol |
| Boxed/Label Warning | Increased risk of bleeding; requires regular monitoring (INR) |
| Purpose | Anticoagulant used to prevent and treat blood clots |
| Mechanism of Action | Vitamin K antagonist; inhibits the synthesis of vitamin K-dependent clotting factors |
| Dosage Forms | Oral tablets |
| Available Strengths | 1 mg, 4 mg |
| Dosage Frequency | Typically once daily, adjusted based on INR levels |
| Common Side Effects | Easy bruising, nosebleeds, bleeding gums, prolonged bleeding from cuts |
| Serious Side Effects | Severe bleeding (internal or external), hemorrhage, skin necrosis |
| Drug Interactions | Aspirin, NSAIDs, antibiotics, antifungals, amiodarone, thyroid medications, many others; consult your healthcare provider or pharmacist |
| Important Notes | Requires regular blood tests (INR) to monitor effectiveness and adjust dosage; consistent Vitamin K intake is important; inform all healthcare providers you are taking this medication. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember on the same day; if remembered on the next day, skip the dose and continue with regular schedule. Do not double the dose. Contact your doctor for instructions. |
| Alternatives | Warfarin (Coumadin), Rivaroxaban (Xarelto), Apixaban (Eliquis), Dabigatran (Pradaxa) |
Sintrom Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Warfarin (Coumadin) | Vitamin K antagonist | Requires regular INR monitoring; long history of use. |
| Rivaroxaban (Xarelto) | Direct factor Xa inhibitor | Does not require routine INR monitoring. |
| Apixaban (Eliquis) | Direct factor Xa inhibitor | Does not require routine INR monitoring. |
| Dabigatran (Pradaxa) | Direct thrombin inhibitor | Does not require routine INR monitoring. |
Sintrom Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Easy bruising | Severe bleeding (internal or external) |
| Nosebleeds | Hemorrhage |
| Bleeding gums | Skin necrosis |
| Prolonged bleeding from cuts | Purple toe syndrome |
| Heavy menstrual periods | Spinal or epidural hematoma (if undergoing spinal procedures) |
Sintrom Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Atrial Fibrillation (prevention of stroke) | Varies based on INR and individual factors. | Adjusted based on INR levels (target INR typically 2.0-3.0). | Take at the same time each day; adhere to INR monitoring schedule. |
| Venous Thromboembolism (DVT/PE) Treatment | Varies based on INR and individual factors. | Adjusted based on INR levels (target INR typically 2.0-3.0). | Take at the same time each day; adhere to INR monitoring schedule. |
| Mechanical Heart Valve (prevention of thromboembolism) | Varies based on INR and individual factors. | Adjusted based on INR levels (target INR may be higher, e.g., 2.5-3.5, depending on valve type). | Take at the same time each day; adhere to INR monitoring schedule. |
