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Soriatane (Acitretin)
| Acitretin (Generic) Acitretin | ||||||
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Shipped from Canada | ||||||
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| Acitretin (Generic) Acitretin | ||||||
Shipped from United Kingdom | ||||||
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| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
General Medication Fact Sheet for Soriatane
| Field | Information |
|---|---|
| Medication Name | Soriatane |
| Generic Name | Acitretin |
| Boxed/Label Warning | Soriatane is a teratogen; it can cause severe birth defects. Females must not be pregnant or become pregnant during treatment or for 3 years after stopping treatment. |
| Purpose | Treatment of severe psoriasis. |
| Mechanism of Action | A retinoid that modulates epithelial cell differentiation, keratinization, and inflammation. |
| Dosage Forms | Oral capsules |
| Available Strengths | 10 mg, 17.5 mg, 25 mg |
| Dosage Frequency | Once daily, typically with a main meal. |
| Common Side Effects | Dry skin, chapped lips, dry eyes, hair loss, peeling skin, elevated triglycerides. |
| Serious Side Effects | Hepatitis, pancreatitis, skeletal hyperostosis, vision changes, pseudotumor cerebri, severe skin reactions (e.g., Stevens-Johnson syndrome). |
| Drug Interactions | Alcohol, tetracycline antibiotics, Methotrexate, vitamin A supplements, phenytoin. |
| Important Notes | Females of reproductive potential must use effective contraception during and for 3 years after treatment. Regular blood tests and eye exams are required. Avoid donating blood during and for 3 years after treatment. Take with food to increase absorption. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember, unless it is almost time for your next dose. Do not double the dose. |
| Alternatives | Methotrexate, Cyclosporine, Apremilast (Otezla), Etanercept (Enbrel) |
Soriatane Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Methotrexate | Folic acid antagonist; inhibits DNA synthesis and cell proliferation. | Often used as a first-line systemic treatment for psoriasis. Requires regular monitoring of liver and blood counts. |
| Cyclosporine | Calcineurin inhibitor; suppresses T-cell activation. | Effective for short-term control of severe psoriasis. Can cause kidney problems and high blood pressure. |
| Apremilast (Otezla) | Phosphodiesterase 4 (PDE4) inhibitor; reduces inflammation. | Oral medication; generally well-tolerated but may cause diarrhea and nausea. |
| Etanercept (Enbrel) | TNF-alpha inhibitor; blocks the activity of TNF-alpha, a key inflammatory cytokine. | Biologic injectable medication; increases the risk of infections. |
Soriatane Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Dry skin | Hepatitis (liver inflammation) |
| Chapped lips | Pancreatitis (inflammation of the pancreas) |
| Dry eyes | Skeletal hyperostosis (excessive bone growth) |
| Hair loss | Vision changes (e.g., decreased night vision) |
| Peeling skin | Pseudotumor cerebri (increased pressure in the skull) |
| Elevated triglycerides | Severe skin reactions (e.g., Stevens-Johnson syndrome) |
Soriatane Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Severe Psoriasis | 25 mg once daily | 25-50 mg once daily | Take with a main meal to increase absorption. Dosage may be adjusted based on response and side effects. |
