Notice: Images are for illustration only and may not reflect the exact product you receive. Brand-name medications may look different depending on their country of origin—Canadian versions, for example, often include a "PR" symbol on the packaging. Rest assured, the medication, dosage, and active ingredients will be exactly as prescribed. Canada Pharmacy Store is committed to your health and safety, and we work only with licensed pharmacies to ensure you receive trusted, high-quality medication every time.
Spironolactone (Generic)
| Aldactone Spironolactone | ||||||
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Shipped from Canada | ||||||
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| Aldactone Spironolactone | ||||||
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Shipped from Mauritius | ||||||
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| Select product strength & quantity:
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General Medication Fact Sheet for Spironolactone
| Field | Information |
|---|---|
| Generic Name | Spironolactone |
| Brand Name Versions | Aldactone |
| Boxed/Label Warning | Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats. Only use for approved conditions. |
| Purpose | Potassium-sparing diuretic; used to treat high blood pressure, heart failure, edema, and hyperaldosteronism. Also used off-label for acne and hirsutism in women. |
| Mechanism of Action | Competitively inhibits aldosterone receptors in the kidneys, leading to increased sodium and water excretion and potassium retention. |
| Dosage Forms | Oral tablets |
| Available Strengths | 25 mg, 50 mg, 100 mg |
| Dosage Frequency | Typically once or twice daily, as directed by a healthcare provider. |
| Common Side Effects | Dizziness, headache, nausea, vomiting, diarrhea, stomach cramps, breast tenderness, irregular menstrual periods, impotence (in men). |
| Serious Side Effects | Hyperkalemia (high potassium), dehydration, kidney problems, severe allergic reactions (rash, itching, swelling, difficulty breathing), Stevens-Johnson Syndrome. |
| Drug Interactions | ACE inhibitors, ARBs, potassium supplements, NSAIDs, digoxin, lithium, alcohol. |
| Important Notes | Avoid potassium supplements or salt substitutes containing potassium while taking this medication. Monitor potassium levels regularly. Consult a doctor if you have kidney or liver problems. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Triamterene, Amiloride, Eplerenone, Furosemide, Hydrochlorothiazide. |
Spironolactone Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Triamterene (Dyrenium) | Potassium-sparing diuretic that blocks sodium channels in the distal tubule. | Often combined with thiazide diuretics. |
| Amiloride (Midamor) | Potassium-sparing diuretic that blocks sodium channels in the distal tubule. | Less potent than spironolactone for treating hyperaldosteronism. |
| Eplerenone (Inspra) | Selective aldosterone blocker. | May have fewer hormonal side effects compared to spironolactone. |
| Furosemide (Lasix) | Loop diuretic that inhibits sodium and chloride reabsorption in the loop of Henle. | More potent diuretic than spironolactone but can lead to potassium loss. |
| Hydrochlorothiazide (Microzide) | Thiazide diuretic that inhibits sodium reabsorption in the distal tubule. | Commonly used for hypertension, can cause potassium loss. |
Spironolactone Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Dizziness | Hyperkalemia (high potassium) |
| Headache | Dehydration |
| Nausea | Kidney problems |
| Vomiting | Severe allergic reactions (rash, itching, swelling, difficulty breathing) |
| Diarrhea | Stevens-Johnson Syndrome |
| Stomach cramps | Irregular heart beat |
Spironolactone Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| High Blood Pressure | 25-100 mg daily | As directed by physician | Can be taken with or without food. |
| Heart Failure | 12.5-25 mg daily | Up to 50 mg daily | Monitor potassium levels. |
| Edema | 25-200 mg daily | As directed by physician | May be taken in divided doses. |
| Hyperaldosteronism | 100-400 mg daily | As directed by physician | Adjust based on potassium levels and response. |
| Acne (off-label, women) | 25-100 mg daily | As directed by physician | Typically taken once or twice daily. |
Spironolactone Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $5 |
| Without Insurance (U.S.) | $30 |
| From CPS | $10 |
