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General Medication Fact Sheet for Sporanox
| Field | Information |
|---|---|
| Medication Name | Sporanox |
| Generic Name | Itraconazole |
| Boxed/Label Warning | May cause heart failure; use caution in patients with risk factors. May cause liver problems. Avoid use during pregnancy. |
| Purpose | Antifungal medication used to treat various fungal infections |
| Mechanism of Action | Inhibits the synthesis of ergosterol, a crucial component of fungal cell membranes |
| Dosage Forms | Oral capsules, oral solution |
| Available Strengths | 100 mg capsules, 10 mg/mL oral solution |
| Dosage Frequency | Varies depending on the infection being treated; typically once or twice daily |
| Common Side Effects | Nausea, vomiting, abdominal pain, headache, dizziness |
| Serious Side Effects | Heart failure, liver problems, severe allergic reactions, Stevens-Johnson syndrome |
| Drug Interactions | Many, including certain statins, calcium channel blockers, benzodiazepines, and other antifungals. Consult a pharmacist or doctor. |
| Important Notes | Take Sporanox capsules with a full meal for best absorption. Take Sporanox oral solution on an empty stomach. Notify your doctor if you have a history of heart or liver problems. |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. |
| Alternatives | Fluconazole (Diflucan), Terbinafine (Lamisil), Ketoconazole, Griseofulvin |
Sporanox Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Fluconazole (Diflucan) | Inhibits fungal cytochrome P450 enzyme 14-alpha demethylase, leading to ergosterol depletion. | Commonly used for yeast infections. Available in oral and IV forms. |
| Terbinafine (Lamisil) | Inhibits squalene epoxidase, an enzyme necessary for ergosterol synthesis. | Primarily used for nail and skin fungal infections. |
| Ketoconazole | Inhibits the synthesis of ergosterol. | Can have more significant side effects and drug interactions than other azole antifungals; use is now limited. |
| Griseofulvin | Inhibits fungal cell mitosis by interfering with the microtubule structure. | Primarily used for skin, hair, and nail infections. |
Sporanox Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Heart failure |
| Vomiting | Liver problems (e.g., jaundice, dark urine) |
| Abdominal pain | Severe allergic reactions (rash, itching, swelling, difficulty breathing) |
| Headache | Stevens-Johnson syndrome (severe skin rash) |
| Dizziness | Peripheral neuropathy (numbness, tingling, or pain in the extremities) |
Sporanox Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Onychomycosis (Fingernail) | 200 mg once daily | 200 mg once daily for 12 weeks | Take capsules with a full meal. |
| Onychomycosis (Toenail) | 200 mg once daily | 200 mg once daily for 12 weeks | Take capsules with a full meal. |
| Oral Thrush | 200 mg once daily | 200 mg once daily for 1-2 weeks | Take the oral solution on an empty stomach. |
| Esophageal Candidiasis | 100 mg once daily | 100 mg once daily for at least 3 weeks | Take the oral solution on an empty stomach. |
Sporanox Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $50 |
| Without Insurance (U.S.) | $400 |
| From CPS | $223 |
