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Sprycel (Dasatinib)
| Dasatinib (Generic) Dasatinib | ||||||
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Shipped from Canada | ||||||
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| Dasatinib (Generic) Dasatinib | ||||||
Shipped from United Kingdom | ||||||
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| Dasatinib (Generic) Dasatinib | ||||||
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Shipped from Mauritius | ||||||
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General Medication Fact Sheet for Sprycel
| Field | Information |
|---|---|
| Medication Name | Sprycel |
| Generic Name | Dasatinib |
| Boxed/Label Warning | May cause myelosuppression (decreased blood cell counts), bleeding, fluid retention, and pulmonary arterial hypertension (PAH). |
| Purpose | Tyrosine kinase inhibitor used to treat certain types of leukemia (chronic myeloid leukemia or CML, and acute lymphoblastic leukemia or ALL). |
| Mechanism of Action | Inhibits multiple tyrosine kinases, including BCR-ABL, SRC-family kinases, c-KIT, and PDGFR, leading to inhibition of cancer cell growth. |
| Dosage Forms | Oral tablets |
| Available Strengths | 20 mg, 50 mg, 70 mg, 80 mg, 100 mg, 140 mg |
| Dosage Frequency | Typically once daily, or as directed by a healthcare provider. |
| Common Side Effects | Nausea, vomiting, diarrhea, fatigue, rash, headache, muscle pain, joint pain. |
| Serious Side Effects | Myelosuppression (low blood counts), bleeding, fluid retention (pleural effusion, edema), pulmonary arterial hypertension (PAH), heart problems, tumor lysis syndrome. |
| Drug Interactions | Strong CYP3A4 inhibitors (e.g., ketoconazole), strong CYP3A4 inducers (e.g., rifampin), antacids (separate administration), proton pump inhibitors (PPIs), H2-receptor antagonists. |
| Important Notes | Take at the same time each day. Avoid taking with antacids. Monitor blood counts regularly. Report any signs of bleeding, fluid retention, or breathing difficulties. Consult your doctor before taking any new medications or supplements. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose. |
| Alternatives | Gleevec (imatinib), Tasigna (nilotinib), Bosulif (bosutinib), Iclusig (ponatinib) |
Sprycel Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Gleevec (imatinib) | Tyrosine kinase inhibitor | First-generation TKI, effective for many CML patients. |
| Tasigna (nilotinib) | Tyrosine kinase inhibitor | Second-generation TKI, may be more potent than imatinib. |
| Bosulif (bosutinib) | Tyrosine kinase inhibitor | Second-generation TKI, targets both BCR-ABL and SRC kinases. |
| Iclusig (ponatinib) | Tyrosine kinase inhibitor | Third-generation TKI, effective against T315I mutation. |
Sprycel Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Myelosuppression (low blood counts) |
| Vomiting | Bleeding |
| Diarrhea | Fluid retention (pleural effusion, edema) |
| Fatigue | Pulmonary arterial hypertension (PAH) |
| Rash | Heart problems (arrhythmias, heart failure) |
| Headache | Tumor lysis syndrome |
| Muscle Pain | Infections |
| Joint Pain | Severe skin reactions (Stevens-Johnson syndrome) |
Sprycel Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Chronic Myeloid Leukemia (CML) – Chronic Phase | 100 mg once daily | 100 mg once daily (adjust based on response and tolerability) | May be taken with or without food. |
| Chronic Myeloid Leukemia (CML) – Accelerated or Blast Phase | 70 mg twice daily | 70 mg twice daily (adjust based on response and tolerability) | May be taken with or without food. |
| Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL) | 70 mg twice daily | 70 mg twice daily (adjust based on response and tolerability) | May be taken with or without food. |
Sprycel Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $50 |
| Without Insurance (U.S.) | $17,000 |
| From CPS | $7,358 |
