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Stalevo (Carbidopa,Levodopa,Entacapone)
| Carbidopa/Levodopa/Entacapone (Generic) Carbidopa, Levodopa, Entacapone | ||||||
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Shipped from Mauritius | ||||||
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Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
General Medication Fact Sheet for Stalevo
| Field | Information |
|---|---|
| Medication Name | Stalevo |
| Generic Name | Carbidopa, Levodopa, and Entacapone |
| Boxed/Label Warning | May cause or worsen dyskinesia (uncontrolled movements) and can cause changes in mental status. Monitor patients for the emergence of depression, suicidal thoughts, or other mood changes. |
| Purpose | Treatment of Parkinson’s disease |
| Mechanism of Action | Levodopa converts to dopamine in the brain, carbidopa prevents levodopa breakdown in the periphery, and entacapone inhibits COMT, prolonging levodopa’s effect. |
| Dosage Forms | Oral tablets |
| Available Strengths | Varies (e.g., 50/12.5/200 mg, 75/18.75/200 mg, 100/25/200 mg, 125/31.25/200 mg, 150/37.5/200 mg, 200/50/200 mg of levodopa/carbidopa/entacapone) |
| Dosage Frequency | Typically taken multiple times daily, as directed by a healthcare provider. |
| Common Side Effects | Nausea, dyskinesia (uncontrolled movements), dizziness, constipation, diarrhea, insomnia, dry mouth. |
| Serious Side Effects | Hallucinations, psychosis, severe dyskinesia, hypotension, neuroleptic malignant syndrome (NMS), rhabdomyolysis. |
| Drug Interactions | MAO inhibitors, nonselective MAO inhibitors, dopamine antagonists, iron supplements, metoclopramide. |
| Important Notes | Do not stop taking this medication suddenly without consulting your doctor. Monitor for changes in mood, behavior, or any unusual side effects. Take consistently with regard to meals for optimal absorption. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Sinemet (carbidopa/levodopa), Rytary (carbidopa/levodopa), Duopa (carbidopa/levodopa enteral suspension), Comtan (entacapone). |
Stalevo Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Sinemet (carbidopa/levodopa) | Levodopa converts to dopamine in the brain, carbidopa prevents levodopa breakdown in the periphery. | Standard treatment for Parkinson’s disease; does not contain entacapone. |
| Rytary (carbidopa/levodopa) | Extended-release form of carbidopa/levodopa. | May provide more consistent dopamine levels and reduce wearing-off effects. |
| Duopa (carbidopa/levodopa enteral suspension) | Carbidopa/levodopa administered directly into the small intestine. | For advanced Parkinson’s disease; requires a surgically placed tube. |
| Comtan (entacapone) | COMT inhibitor that prolongs the effect of levodopa. | Used as an add-on therapy to carbidopa/levodopa. |
Stalevo Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Hallucinations |
| Dyskinesia (uncontrolled movements) | Psychosis |
| Dizziness | Severe dyskinesia |
| Constipation | Hypotension |
| Diarrhea | Neuroleptic Malignant Syndrome (NMS) |
| Insomnia | Rhabdomyolysis |
| Dry Mouth | Changes in mental status, depression, suicidal thoughts |
Stalevo Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Parkinson’s Disease (Levodopa Naive) | Typically start with a low dose (e.g., 50/12.5/200 mg) | Individualized based on response and tolerance. | Administer with or without food, but consistently. Dosage adjustments should be made gradually under medical supervision. |
| Parkinson’s Disease (Switching from Carbidopa/Levodopa) | Dosage is calculated based on previous levodopa dose and adjusted as needed. | Individualized based on response and tolerance. | Carefully monitor for changes in motor function during the switch. |
Stalevo Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $30 |
| Without Insurance (U.S.) | $450 |
| From CPS | $190 |
