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Stelara (Ustekinumab)
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General Medication Fact Sheet for Stelara
| Field | Information |
|---|---|
| Medication Name | Stelara |
| Generic Name | Ustekinumab |
| Boxed/Label Warning | Increased risk of serious infections; screen for latent tuberculosis before use. |
| Purpose | Treatment of plaque psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis. |
| Mechanism of Action | Human interleukin-12 and interleukin-23 antagonist; disrupts inflammatory pathways. |
| Dosage Forms | Subcutaneous injection, intravenous infusion |
| Available Strengths | 45 mg/0.5 mL, 90 mg/mL |
| Dosage Frequency | Varies by condition: Initial dose, then maintenance doses every 8-12 weeks. |
| Common Side Effects | Upper respiratory infections, headache, fatigue, injection site reactions. |
| Serious Side Effects | Serious infections (bacterial, viral, fungal), malignancies, allergic reactions. |
| Drug Interactions | Live vaccines, immunosuppressants (e.g., cyclosporine, azathioprine). |
| Important Notes | Monitor for signs of infection; avoid live vaccines; consult your doctor before starting any new medications. |
| Storage | Store refrigerated at 2-8°C (36-46°F); protect from light. Do not freeze. |
| Missed Dose | Contact your healthcare provider for instructions. Do not double the dose. |
| Alternatives | Humira (adalimumab), Skyrizi (risankizumab), Cosentyx (secukinumab), Taltz (ixekizumab) |
Stelara Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Humira (adalimumab) | TNF-alpha inhibitor | Used for similar conditions, requires more frequent dosing. |
| Skyrizi (risankizumab) | IL-23 inhibitor | Another biologic used for psoriasis and Crohn’s disease. |
| Cosentyx (secukinumab) | IL-17A inhibitor | Used for psoriasis and psoriatic arthritis. |
| Taltz (ixekizumab) | IL-17A inhibitor | Another biologic option for psoriasis and psoriatic arthritis. |
Stelara Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Upper respiratory infections | Serious infections (pneumonia, cellulitis) |
| Headache | Malignancies (skin cancer, lymphoma) |
| Fatigue | Severe allergic reactions (anaphylaxis) |
| Injection site reactions (redness, pain) | Reversible Posterior Leukoencephalopathy Syndrome (RPLS) |
| Joint Pain | New onset or worsening psoriasis |
Stelara Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Plaque Psoriasis | 45 mg or 90 mg based on weight | Same dose every 12 weeks | Subcutaneous injection. |
| Psoriatic Arthritis | 45 mg | 45 mg every 12 weeks | Subcutaneous injection. |
| Crohn’s Disease | Weight-based IV infusion | 90 mg every 8 weeks | Subcutaneous injection. |
| Ulcerative Colitis | Weight-based IV infusion | 90 mg every 8 weeks or 12 weeks | Subcutaneous injection. |
Stelara Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $200 |
| Without Insurance (U.S.) | $45,000 |
| From Canada | $6,000 |
