Notice: Images are for illustration only and may not reflect the exact product you receive. Brand-name medications may look different depending on their country of origin—Canadian versions, for example, often include a "PR" symbol on the packaging. Rest assured, the medication, dosage, and active ingredients will be exactly as prescribed. Canada Pharmacy Store is committed to your health and safety, and we work only with licensed pharmacies to ensure you receive trusted, high-quality medication every time.
Description
General Medication Fact Sheet for Stivarga
| Field | Information |
|---|---|
| Medication Name | Stivarga |
| Generic Name | Regorafenib |
| Boxed/Label Warning | Severe liver problems. Stivarga can cause severe and sometimes fatal liver problems. Your doctor should do blood tests to check your liver function before you start taking Stivarga and during your treatment. Tell your doctor right away if you develop any of the following signs or symptoms of liver problems: yellowing of your skin or the whites of your eyes (jaundice), dark urine, light-colored stools (bowel movements), nausea, vomiting, loss of appetite, pain on the right side of your stomach area, tiredness, feel weak, bleeding or bruising more easily than normal. Increased risk of bleeding. Stivarga can increase your risk of bleeding. Tell your doctor if you develop any signs of bleeding during treatment with Stivarga, including black, tarry stools, blood in your stools, or vomit that looks like coffee grounds. Skin problems, including hand-foot skin reaction. Stivarga can cause skin problems, including hand-foot skin reaction (HFSR) and severe skin rashes. Tell your doctor right away if you develop any skin problems during treatment with Stivarga, including: pain, redness, swelling, blisters, or peeling skin on your hands and feet. HFSR can be severe and may require treatment with other medicines, dose reductions or stopping Stivarga. |
| Purpose | Tyrosine kinase inhibitor used to treat certain types of cancer, including metastatic colorectal cancer, gastrointestinal stromal tumors (GIST), and hepatocellular carcinoma (liver cancer). |
| Mechanism of Action | Inhibits several protein kinases involved in tumor angiogenesis, oncogenesis, and the tumor microenvironment. |
| Dosage Forms | Oral tablets |
| Available Strengths | 40 mg |
| Dosage Frequency | Once daily for the first 21 days of each 28-day cycle, or as directed by a healthcare provider. |
| Common Side Effects | Weakness or fatigue, decreased appetite, hand-foot skin reaction, diarrhea, mucositis, weight loss, infection, hypertension, dysphonia. |
| Serious Side Effects | Liver damage, severe bleeding, gastrointestinal perforation, wound healing complications, hypertension, cardiac ischemia and infarction, reversible posterior leukoencephalopathy syndrome (RPLS). |
| Drug Interactions | Strong CYP3A4 inducers (e.g., rifampin, phenytoin), strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin), drugs metabolized by UGT1A1 (e.g., irinotecan). |
| Important Notes | Take after a low-fat meal; swallow tablets whole with water; monitor liver function, blood pressure, and signs of bleeding or infection; avoid grapefruit and grapefruit juice. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | If a dose is missed, take it as soon as you remember unless it is close to the time of the next dose. Do not double the dose. |
| Alternatives | Lenvatinib (Lenvima), Sorafenib (Nexavar), Cabozantinib (Cabometyx) |
Stivarga Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Lenvatinib (Lenvima) | Tyrosine kinase inhibitor | Used for hepatocellular carcinoma and other cancers. |
| Sorafenib (Nexavar) | Tyrosine kinase inhibitor | Also used for hepatocellular carcinoma and renal cell carcinoma. |
| Cabozantinib (Cabometyx) | Tyrosine kinase inhibitor | Used for hepatocellular carcinoma and renal cell carcinoma. |
Stivarga Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Weakness or fatigue | Liver damage |
| Decreased appetite | Severe bleeding |
| Hand-foot skin reaction | Gastrointestinal perforation |
| Diarrhea | Cardiac ischemia and infarction |
| Hypertension | Reversible posterior leukoencephalopathy syndrome (RPLS) |
Stivarga Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Metastatic Colorectal Cancer | 160 mg (4 tablets) | 160 mg once daily for 21 days, followed by 7 days off | Take after a low-fat meal. |
| Gastrointestinal Stromal Tumors (GIST) | 160 mg (4 tablets) | 160 mg once daily for 21 days, followed by 7 days off | Take after a low-fat meal. |
| Hepatocellular Carcinoma (Liver Cancer) | 160 mg (4 tablets) | 160 mg once daily for 21 days, followed by 7 days off | Take after a low-fat meal. |
Stivarga Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $300 |
| Without Insurance (U.S.) | $11,000 |
| From Canada | $9,334 |
Why Americans Buy Stivarga from Canada Pharmacy Store?
Why Americans Buy Stivarga from Canada Pharmacy Store?
Americans have trouble affording Stivarga due to numerous factors—but at Canada Pharmacy Store, we offer a safe, affordable alternative. That’s why thousands of Americans trust us to fill their prescriptions with real savings and real service.
Big Savings on U.S. Medications
Our customers save up to 80% on their Stivarga prescriptions compared to U.S. pharmacy prices by ordering through licensed Canadian and international pharmacies.
Free Prescription Transfers
We make it easy! Our pharmacy team can transfer your Stivarga prescriptions directly from your doctor or local pharmacy – completely free of charge.
Direct Access to Experts
Our licensed pharmacists are available to support you, answer your questions, and help ensure you’re confident in your treatment.
Referral Discounts
Spread the word—when you refer friends or family, you both save. It’s our way of saying thanks.
Discreet U.S. Shipping
All orders are packaged discreetly and shipped securely to your U.S. address, with your privacy and safety as top priorities.
Trusted by Americans Nationwide
With years of experience and verified medication sources, we’ve become a go-to solution for Americans looking to cut costs without compromising care.
How to Order Stivarga Online
How to Order Stivarga Online
Step 1
Select Your Prescribed Stivarga Dosage
Choose the strength and quantity as directed by your healthcare provider and add it to your cart.
Step 2
Proceed Through Secure Checkout
Follow the steps to complete your order and provide necessary shipping and payment details.
Step 3
Upload Your Stivarga Prescription
Submit a prescription from a licensed U.S. healthcare provider that matches your order.
At Canada Pharmacy Store, patient safety comes first. We strictly comply with prescription regulations and do not ship any medication without a valid, verifiable prescription. Orders may be declined if a prescription appears falsified or altered in any way. We take these precautions to protect your health and ensure lawful, responsible practices.
Guarantee
Our Guarantee When You Buy Stivarga Through Canada Pharmacy Store
At Canada Pharmacy Store, your safety and satisfaction are our top priorities. We supply only authentic, high-quality medications by working exclusively with licensed Canadian pharmacies and trusted international partners. Every order is filled in accordance with strict regulatory standards and includes medication that’s fully approved by Health Canada or other recognized health authorities such as the MHRA (UK), HSA (Singapore), and the Pharmacy Board of Mauritius.
The Stivarga you receive is the same active medication as what’s available in the U.S.—the only difference is the packaging, which reflects its country of origin. Our licensed healthcare professionals review each order carefully to ensure it matches your prescription exactly.
To get Stivarga at a lower price, simply place your order above or give us a call at 1-888-903-2240
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