| Medication Name | Stribild |
| Generic Name | Emtricitabine/Tenofovir Disoproxil Fumarate/Elvitegravir/Cobicistat |
| Boxed/Label Warning | Exacerbations of hepatitis B (HBV) have been reported in patients who are co-infected with HIV-1 and HBV and have discontinued Stribild. Renal impairment, including cases of acute renal failure and Fanconi syndrome, has been reported with the use of tenofovir disoproxil fumarate. |
| Purpose | Complete HIV-1 treatment regimen used alone to treat HIV-1 infection in adults. |
| Mechanism of Action | Contains four drugs that work to block HIV replication at different stages of the viral life cycle. Emtricitabine and tenofovir are nucleoside reverse transcriptase inhibitors (NRTIs), elvitegravir is an integrase strand transfer inhibitor (INSTI), and cobicistat is a CYP3A inhibitor that boosts elvitegravir levels. |
| Dosage Forms | Oral tablets |
| Available Strengths | 200 mg emtricitabine / 300 mg tenofovir disoproxil fumarate / 150 mg elvitegravir / 150 mg cobicistat |
| Dosage Frequency | Once daily |
| Common Side Effects | Nausea, diarrhea, fatigue, headache, dizziness, abnormal dreams, insomnia |
| Serious Side Effects | Kidney problems (including kidney failure), bone problems (decreased bone mineral density), lactic acidosis (buildup of acid in the blood), liver problems, new or worsening HBV infection after discontinuation. |
| Drug Interactions | Many drugs can interact with Stribild. Discuss all medications, supplements, and herbal products with your doctor or pharmacist. Significant interactions include certain antiarrhythmics, anticonvulsants, antimycobacterials, and St. John’s Wort. |
| Important Notes | Stribild is a complete regimen and should not be taken with other HIV medications. It should be taken with food to help with absorption. Do not take if you have severe kidney or liver problems. Consult a healthcare provider for comprehensive advice. |
| Storage | Store at room temperature (20-25°C or 68-77°F), away from moisture and light. |
| Missed Dose | Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up. |
| Alternatives | Genvoya (elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide), Biktarvy (bictegravir/emtricitabine/tenofovir alafenamide), Triumeq (dolutegravir/abacavir/lamivudine) |