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General Medication Fact Sheet for Stronghold
| Field | Information |
|---|---|
| Medication Name | Stronghold |
| Generic Name | Selamectin |
| Purpose | Parasiticide used to prevent heartworm disease and treat ear mites, fleas, and certain types of ticks and worms in dogs and cats |
| Mechanism of Action | Interferes with the chloride ion channels in invertebrates nerve and muscle cells, causing paralysis and death of the parasites |
| Dosage Forms | Topical solution |
| Available Strengths | Various strengths depending on animal weight (e.g., 15 mg, 30 mg, 45 mg, 60 mg, 120 mg, 240 mg) |
| Dosage Frequency | Monthly |
| Common Side Effects | Temporary hair loss at the application site, skin irritation, itching |
| Serious Side Effects | Drooling, incoordination, vomiting, diarrhea, anorexia (rare) |
| Drug Interactions | Generally safe with most other medications; consult with a veterinarian about specific combinations |
| Important Notes | Use only on dogs and cats over 6 weeks of age; apply topically to the skin at the base of the neck in front of the shoulder blades where the animal cannot lick it off; avoid contact with skin and eyes during application |
| Storage | Store at room temperature, away from heat and direct sunlight |
| Missed Dose | Apply as soon as you remember, then resume the regular monthly schedule |
| Alternatives | Revolution (selamectin), Advantage Multi (imidacloprid and moxidectin), Heartgard Plus (ivermectin and pyrantel) |
Stronghold Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Revolution (selamectin) | Interferes with chloride ion channels in parasites | Contains the same active ingredient (selamectin) as Stronghold. |
| Advantage Multi (imidacloprid and moxidectin) | Imidacloprid affects the nerve cells of insects; moxidectin interferes with nerve and muscle function of parasites. | Broader spectrum of activity, including fleas, heartworm, and intestinal worms. |
| Heartgard Plus (ivermectin and pyrantel) | Ivermectin paralyzes parasites; pyrantel paralyzes intestinal worms. | Primarily for heartworm prevention and intestinal worm treatment. Does not treat fleas or ticks. |
Stronghold Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Temporary hair loss at application site | Drooling |
| Skin irritation | Incoordination |
| Itching | Vomiting |
| Back pain or joint pain | Diarrhea |
| Diarrhea | Anorexia |
Stronghold Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Fleas | Based on animal’s weight | Monthly application based on animal’s weight | Apply to the skin at the base of the neck. |
| Ear Mites | Based on animal’s weight | Monthly application based on animal’s weight | Apply to the skin at the base of the neck. |
| Heartworm Prevention | Based on animal’s weight | Monthly application based on animal’s weight | Apply to the skin at the base of the neck. Start before mosquito season. |
| Ticks (certain species) | Based on animal’s weight | Monthly application based on animal’s weight | Apply to the skin at the base of the neck. |
| Intestinal Worms (certain species) | Based on animal’s weight | Monthly application based on animal’s weight | Apply to the skin at the base of the neck. |
