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General Medication Fact Sheet for Sulfinpyrazone
| Field | Information |
|---|---|
| Generic Name | Sulfinpyrazone |
| Brand Name Versions | Anturane |
| Purpose | Uricosuric agent used to treat gout and hyperuricemia |
| Mechanism of Action | Inhibits renal tubular reabsorption of uric acid, increasing its excretion in the urine |
| Dosage Forms | Oral tablets |
| Available Strengths | 100 mg, 200 mg |
| Dosage Frequency | Typically two to four times daily, or as directed by a healthcare provider |
| Common Side Effects | Stomach pain, nausea, vomiting, indigestion |
| Serious Side Effects | Kidney stones, blood disorders (e.g., leukopenia, thrombocytopenia), allergic reactions |
| Drug Interactions | Warfarin, aspirin, probenecid, other uricosuric agents, certain diuretics |
| Important Notes | Drink plenty of fluids to prevent kidney stones; avoid aspirin; monitor uric acid levels regularly; consult a doctor if you have kidney problems or a history of peptic ulcers |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Allopurinol, Febuxostat, Probenecid |
Sulfinpyrazone Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Allopurinol (Zyloprim) | Xanthine oxidase inhibitor, reduces uric acid production | First-line treatment for chronic gout. |
| Febuxostat (Uloric) | Xanthine oxidase inhibitor, reduces uric acid production | Alternative to Allopurinol, especially for those who cannot tolerate Allopurinol. |
| Probenecid | Uricosuric agent, increases uric acid excretion | May be used in combination with other gout medications. |
Sulfinpyrazone Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Stomach pain | Kidney stones |
| Nausea | Blood disorders (leukopenia, thrombocytopenia) |
| Vomiting | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Indigestion | Gastrointestinal ulceration or bleeding |
Sulfinpyrazone Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Gout | 100-200 mg twice daily | 200-400 mg two to four times daily | Take with food and plenty of fluids. |
| Hyperuricemia | 100 mg twice daily | Up to 800 mg daily in divided doses | Take with food and plenty of fluids. |
