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General Medication Fact Sheet for Sulindac
| Field | Information |
|---|---|
| Generic Name | Sulindac |
| Brand Name Versions | Clinoril (Discontinued in the U.S.) |
| Purpose | Non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and stiffness |
| Mechanism of Action | Inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis |
| Dosage Forms | Oral tablets |
| Available Strengths | 150 mg, 200 mg |
| Dosage Frequency | Typically twice daily, or as directed by a healthcare provider |
| Common Side Effects | Abdominal pain, nausea, diarrhea, constipation, headache |
| Serious Side Effects | Gastrointestinal bleeding, liver problems, kidney problems, allergic reactions, heart problems |
| Drug Interactions | Other NSAIDs, anticoagulants (e.g., warfarin), aspirin, certain antidepressants (SSRIs), ACE inhibitors, diuretics |
| Important Notes | Take with food to minimize stomach upset; avoid alcohol; consult a doctor if you have heart, liver, or kidney problems |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Ibuprofen, Naproxen, Celecoxib, Meloxicam |
Sulindac Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Ibuprofen (Advil, Motrin) | Non-selective COX inhibitor | Commonly used for mild to moderate pain relief. |
| Naproxen (Aleve) | Non-selective COX inhibitor | Longer-lasting pain relief compared to ibuprofen. |
| Celecoxib (Celebrex) | Selective COX-2 inhibitor | May have a lower risk of gastrointestinal side effects compared to non-selective NSAIDs. |
| Meloxicam (Mobic) | Selective COX-2 inhibitor | Once-daily dosing may improve adherence. |
Sulindac Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Abdominal pain | Gastrointestinal bleeding (black, tarry stools; vomiting blood) |
| Nausea | Liver problems (yellowing of skin or eyes, dark urine) |
| Diarrhea | Kidney problems (changes in urination) |
| Constipation | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Headache | Heart problems (chest pain, shortness of breath, weakness on one side of the body) |
Sulindac Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Osteoarthritis | 150 mg twice daily or 200 mg twice daily | 150 mg twice daily or 200 mg twice daily | Take with food to reduce stomach upset. |
| Rheumatoid Arthritis | 150 mg twice daily or 200 mg twice daily | 150 mg twice daily or 200 mg twice daily | Take with food to reduce stomach upset. |
| Ankylosing Spondylitis | 200 mg twice daily | 200 mg twice daily | Take with food to reduce stomach upset. |
