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General Medication Fact Sheet for Sutent
| Field | Information |
|---|---|
| Medication Name | Sutent |
| Generic Name | Sunitinib |
| Boxed/Label Warning | Severe hepatotoxicity, cardiovascular events, hemorrhage, and embryo-fetal toxicity. |
| Purpose | Tyrosine kinase inhibitor used to treat certain types of cancer, including renal cell carcinoma (RCC), gastrointestinal stromal tumor (GIST), and pancreatic neuroendocrine tumors (pNET). |
| Mechanism of Action | Inhibits multiple receptor tyrosine kinases (RTKs) involved in tumor growth, angiogenesis, and metastasis. |
| Dosage Forms | Oral capsules |
| Available Strengths | 12.5 mg, 25 mg, 37.5 mg, 50 mg |
| Dosage Frequency | Typically once daily, often on a schedule of 4 weeks on and 2 weeks off, or as directed by a healthcare provider. |
| Common Side Effects | Fatigue, diarrhea, nausea, vomiting, mucositis, skin discoloration, hand-foot syndrome, hypertension, hypothyroidism. |
| Serious Side Effects | Hepatotoxicity, cardiovascular events (heart failure, myocardial infarction), hemorrhage, hypertension, thyroid dysfunction, tumor lysis syndrome, renal impairment, impaired wound healing, proteinuria. |
| Drug Interactions | Strong CYP3A4 inhibitors (e.g., ketoconazole), strong CYP3A4 inducers (e.g., rifampin), drugs that prolong the QT interval. |
| Important Notes | Monitor blood pressure, thyroid function, and liver function regularly. Report any signs of bleeding, infection, or heart problems to your doctor immediately. Women of childbearing potential should use effective contraception. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose. |
| Alternatives | Axitinib (Inlyta), Sorafenib (Nexavar), Pazopanib (Votrient), Everolimus (Afinitor) |
Sutent Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Axitinib (Inlyta) | Selective inhibitor of vascular endothelial growth factor receptors (VEGFR) 1, 2, and 3. | Used in renal cell carcinoma. |
| Sorafenib (Nexavar) | Inhibits several tyrosine kinases, including VEGFR and RAF kinases. | Used in renal cell carcinoma, hepatocellular carcinoma, and thyroid cancer. |
| Pazopanib (Votrient) | Inhibits multiple receptor tyrosine kinases, including VEGFR, PDGFR, and c-Kit. | Used in renal cell carcinoma and soft tissue sarcoma. |
| Everolimus (Afinitor) | mTOR inhibitor | Used in renal cell carcinoma, pancreatic neuroendocrine tumors, and other cancers. |
Sutent Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Fatigue | Hepatotoxicity (liver damage) |
| Diarrhea | Cardiovascular events (heart failure, myocardial infarction) |
| Nausea | Hemorrhage (bleeding) |
| Vomiting | Hypertension (high blood pressure) |
| Mucositis (inflammation of the mouth) | Thyroid dysfunction |
| Skin discoloration | Tumor lysis syndrome |
| Hand-foot syndrome (palmar-plantar erythrodysesthesia) | Renal impairment (kidney damage) |
| Hypertension | Impaired wound healing |
| Hypothyroidism | Proteinuria (protein in urine) |
Sutent Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Renal Cell Carcinoma (RCC) | 50 mg daily | 50 mg daily for 4 weeks on, 2 weeks off | Take with or without food. |
| Gastrointestinal Stromal Tumor (GIST) | 50 mg daily | 50 mg daily for 4 weeks on, 2 weeks off, or 37.5 mg daily continuously | Take with or without food. |
| Pancreatic Neuroendocrine Tumors (pNET) | 37.5 mg daily | 37.5 mg daily continuously | Take with or without food. |
Sutent Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $250 |
| Without Insurance (U.S.) | $9,000 |
| From CPS | $2,393 |
