| Medication Name | Symtuza |
| Generic Name | Darunavir, Cobicistat, Emtricitabine, Tenofovir alafenamide |
| Boxed/Label Warning | Potential for post-treatment acute exacerbation of hepatitis B in patients who are co-infected with HBV and HIV-1 and have discontinued emtricitabine or tenofovir disoproxil fumarate (TDF). Also, new onset or worsening renal impairment. |
| Purpose | Complete regimen for the treatment of HIV-1 infection in adults and adolescents (12 years of age and older, with a body weight of at least 40 kg) who are virologically suppressed (HIV-1 RNA less than 50 copies per mL) on a stable antiretroviral regimen with no known or suspected resistance to darunavir, emtricitabine, or tenofovir. |
| Mechanism of Action | Symtuza contains darunavir (a protease inhibitor), cobicistat (a CYP3A inhibitor that boosts darunavir levels), emtricitabine (a nucleoside reverse transcriptase inhibitor), and tenofovir alafenamide (a nucleotide reverse transcriptase inhibitor). They work by inhibiting different stages of the HIV replication cycle. |
| Dosage Forms | Oral tablets |
| Available Strengths | Darunavir 800 mg/Cobicistat 150 mg/Emtricitabine 200 mg/Tenofovir alafenamide 10 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Diarrhea, nausea, fatigue, headache |
| Serious Side Effects | Liver problems, kidney problems, new or worsening diabetes, increased cholesterol and triglyceride levels, immune reconstitution syndrome. |
| Drug Interactions | Certain antiarrhythmics, anticonvulsants, antimycobacterials, HMG-CoA reductase inhibitors, immunosuppressants, and other antiretroviral agents. Consult a healthcare provider for a complete list. |
| Important Notes | Take with food. Do not take with other medications containing tenofovir alafenamide, tenofovir disoproxil fumarate or adefovir dipivoxil. Not a cure for HIV-1 infection. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember unless it is close to your next dose. Do not double the dose. |
| Alternatives | Biktarvy, Triumeq, Dovato, Odefsey |