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Synjardy (Empagliflozin, Metformin HCI)
| Synjardy Metformin Hydrochloride, Empagliflozin | ||||||
Shipped from United Kingdom | ||||||
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| Synjardy Metformin Hydrochloride, Empagliflozin | ||||||
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Shipped from Mauritius | ||||||
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| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
General Medication Fact Sheet for Synjardy
| Field | Information |
|---|---|
| Medication Name | Synjardy |
| Generic Name | Empagliflozin and Metformin Hydrochloride |
| Boxed/Label Warning | Lactic Acidosis: Postmarketing cases of Metformin-associated lactic acidosis have resulted in death, requiring hospitalization, and/or intensive care. |
| Purpose | Treatment of type 2 diabetes mellitus to improve glycemic control in adults when diet and exercise are inadequate. |
| Mechanism of Action | Empagliflozin: Sodium-glucose co-transporter 2 (SGLT2) inhibitor, reducing glucose reabsorption in the kidney. Metformin: Decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity. |
| Dosage Forms | Oral tablets |
| Available Strengths | 5 mg/500 mg, 5 mg/1000 mg, 12.5 mg/500 mg, 12.5 mg/1000 mg |
| Dosage Frequency | Twice daily, with meals to decrease gastrointestinal side effects. |
| Common Side Effects | Urinary tract infections, female genital mycotic infections, nausea, diarrhea, flatulence, headache. |
| Serious Side Effects | Lactic acidosis, kidney problems, ketoacidosis, urinary tract infections (severe), hypotension, allergic reactions. |
| Drug Interactions | Insulin and insulin secretagogues (e.g., sulfonylureas), diuretics, other antidiabetic agents, drugs that affect kidney function. |
| Important Notes | Not for use in type 1 diabetes or diabetic ketoacidosis. Monitor kidney function before and during treatment. Avoid excessive alcohol intake. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Metformin, Jardiance (empagliflozin), Janumet (sitagliptin/Metformin), Glipizide. |
Synjardy Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Metformin | Decreases hepatic glucose production and improves insulin sensitivity. | First-line treatment for type 2 diabetes. |
| Jardiance (empagliflozin) | SGLT2 inhibitor; reduces glucose reabsorption in the kidney. | Can be used alone or in combination with other diabetes medications. |
| Janumet (sitagliptin/Metformin) | DPP-4 inhibitor (sitagliptin) and biguanide (Metformin). | Combination medication that can improve glycemic control. |
| Glipizide | Sulfonylurea; stimulates insulin release from the pancreas. | May cause hypoglycemia. |
Synjardy Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Urinary tract infections | Lactic acidosis |
| Female genital mycotic infections | Kidney problems |
| Nausea | Ketoacidosis |
| Diarrhea | Severe urinary tract infections |
| Flatulence | Hypotension |
| Headache | Allergic reactions (rash, itching, swelling, difficulty breathing) |
Synjardy Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Type 2 Diabetes | Empagliflozin 5 mg/Metformin 500 mg twice daily | Individualized based on efficacy and tolerability; maximum daily dose of Empagliflozin 25 mg/Metformin 2000 mg | Take with meals to reduce gastrointestinal side effects. |
Synjardy Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $50 |
| Without Insurance (U.S.) | $450 |
| From CPS | $148 |
