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General Medication Fact Sheet for Synvisc – One
| Field | Information |
|---|---|
| Medication Name | Synvisc – One |
| Generic Name | Hylan G-F 1a |
| Purpose | Viscosupplementation for osteoarthritis knee pain relief. |
| Mechanism of Action | Replaces and supplements synovial fluid, improving joint lubrication and reducing pain. |
| Dosage Forms | Intra-articular injection |
| Available Strengths | 6 mL (1 dose) |
| Dosage Frequency | Single injection |
| Common Side Effects | Pain, swelling, warmth, redness, or fluid build-up in the injected knee; joint pain; muscle pain; nausea; headache |
| Serious Side Effects | Severe allergic reactions (rash, itching, swelling, dizziness, trouble breathing); signs of infection (fever, chills, severe knee pain); pseudoseptic reaction (pain, swelling, joint effusion). |
| Drug Interactions | Avoid using disinfectants containing quaternary ammonium salts for skin preparation. |
| Important Notes | Synvisc-One is injected directly into the knee joint by a healthcare professional. Avoid strenuous activities for 48 hours after the injection. It may take a few weeks to experience the full benefit. |
| Storage | Store at room temperature; protect from freezing. |
| Missed Dose | Since Synvisc-One is a single injection, a ‘missed dose’ is not applicable. |
| Alternatives | Euflexxa, Orthovisc, Monovisc, Corticosteroid Injections, Hyaluronic Acid Injections (various brands) |
Synvisc – One Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Euflexxa (Hyaluronic Acid) | Viscosupplement, improves joint lubrication | Usually requires a series of injections (3 injections). |
| Orthovisc (Hyaluronic Acid) | Viscosupplement, improves joint lubrication | Usually requires a series of injections (3-4 injections). |
| Monovisc (Hyaluronic Acid) | Viscosupplement, improves joint lubrication | Single-injection formulation, similar to Synvisc-One. |
| Corticosteroid Injections | Reduces inflammation in the joint | Provides faster pain relief, but effects are temporary and may not last as long as viscosupplementation. |
Synvisc – One Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Pain, swelling, warmth, or redness at the injection site | Severe allergic reactions (rash, itching, swelling, dizziness, trouble breathing) |
| Joint pain | Signs of infection (fever, chills, severe knee pain) |
| Muscle pain | Pseudoseptic reaction (pain, swelling, joint effusion) |
Synvisc – One Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Osteoarthritis Knee Pain | 6 mL (single injection) | Not applicable (single injection) | Administered intra-articularly by a healthcare professional. Avoid strenuous activities for 48 hours. |
Synvisc – One Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $300 |
| Without Insurance (U.S.) | $1,750 |
| From Canada | $670 |
